机构:[a]Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing首都医科大学宣武医院[b]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing老年医学科首都医科大学宣武医院[c]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing神经内科首都医科大学宣武医院[d]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing神经外科首都医科大学宣武医院[e]Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Health Sciences Center, Beijing, China
Background and purpose: The incidence of ischaemic stroke has increased or remained high in China; however, little population-based evidence is available on the incidence and survival of lacunar infarction (LAC). We examined the incidence of LAC in a northern Chinese (Beijing) population and monitored survival. Methods: A prospective registry population-based study was conducted over a 6-year period in a general, unselected, and representative community in Beijing with approximately 100 000 long-term permanent residents. All first-ever stroke cases were registered. Results: A total of 1184 patients with ischaemic stroke were identified; 36.9% (437 cases) were classified as LAC. Age-standardized incidence rates of LAC ranged from 24.0 to 51.3/100 000 with an average rate of 35.3/100 000 during study period. The incidence of LAC increased with age before 70 years. The incidence of non-LAC increased with age. There were no significant differences in crude incidence of LAC between men and women (78.4/100 000 vs. 75.4/100 000). The incidence of non-LAC was significantly higher in men than in women (155/100 000 vs. 107/100 000, P < 0.001). The 28-day case fatality proportions were significantly lower in patients with LAC (0.5%) versus non-LAC (14.9%). One year after acute stroke onset, the survival rates between LAC and non-LAC were similar. Conclusion: LAC is a common stroke subtype in Northern China. Men or the elderly are more likely to have non-LAC. Long-term survival following LAC is similar to non-LAC patients.
基金:
National Natural Science Foundation of China (projects 30671797 and 81072361)
第一作者机构:[a]Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing
通讯作者:
通讯机构:[*1]Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Health Sciences Center, Beijing 100191, China
推荐引用方式(GB/T 7714):
X.-H. Fang,W.-H. Wang,X.-Q. Zhang,et al.Incidence and survival of symptomatic lacunar infarction in a Beijing population: a 6-year prospective study[J].EUROPEAN JOURNAL OF NEUROLOGY.2012,19(8):1114-1120.doi:10.1111/j.1468-1331.2012.03709.x.
APA:
X.-H. Fang,W.-H. Wang,X.-Q. Zhang,H.-J. Liu,H.-M. Zhang...&L.-M. Li.(2012).Incidence and survival of symptomatic lacunar infarction in a Beijing population: a 6-year prospective study.EUROPEAN JOURNAL OF NEUROLOGY,19,(8)
MLA:
X.-H. Fang,et al."Incidence and survival of symptomatic lacunar infarction in a Beijing population: a 6-year prospective study".EUROPEAN JOURNAL OF NEUROLOGY 19..8(2012):1114-1120