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Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury

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收录情况： ◇ SCIE

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机构： [a]Department of Neurosurgery, The Affiliated Hospital of Weifang Medical College, Weifang, Shandong 261031, China [b]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA [c]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [d]Butler College, Princeton University, NJ, USA [e]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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关键词： Stroke Brain edema MMP-2 MMP-9 AQP-4 AQP-9

摘要：

Background and purpose: Ethanol has been shown to provide neuroprotective effects, but the precise mechanisms by which these effects occur have yet to be investigated. In this study, we investigate blood brain barrier (BBB) and edema level changes in association with expression of matrix metalloproteinases (MMP-2 and MMP-9) and aquaporins (AQP-4 and AQP-9) in ethanol treated rats following middle cerebral artery (MCA) occlusion. Methods: An ischemic stroke model was generated by occlusion of the right MCA for 2 h in male Sprague Dawley rats (n=72). Edema levels and BBB integrity following the ischemic event were studied by quantification of brain water content and extravasadon of Evans blue following 24 and 48 h of reperfusion, respectively. Expression of the proteins MMP-2 and MMP-9, as well as AQP-4 and AQP-9, were determined by Western blot analysis 3 and 24 h after reperfusion. Results: Treatment with ethanol significantly reduced brain edema (P<0.01) and BBB dysfunction (P<0.05) when compared to the saline-treated control groups. The upregulation of MMP-2 and MMP-9, as well as AQP-4 and AQP-9, following ischemia/reperfusion, was significantly reduced in ethanol-treated groups (P<0.05). Conclusions: Ethanol ameliorates brain edema and BBB disruption after stroke, in association with a reduction in the expression of MMPs and AQPs. These results provide clues to ethanol's neuroprotective properties. (C) 2011 Elsevier B.V. All rights reserved.

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出版当年[2011]版：

大类 | 3 区医学

小类 | 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2010]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.9 最新五年平均 2.623 出版当年[2010版] 2.665 出版当年五年平均 2.463 出版前一年[2009版] 2.728 出版后一年[2011版]

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第一作者机构： [a]Department of Neurosurgery, The Affiliated Hospital of Weifang Medical College, Weifang, Shandong 261031, China

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通讯作者：

通讯机构： [*1]Department of Neurosurgery, Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100046, China. [*2]Department of Neurological Surgery, Wayne State University School of Medicine, 550 E Canfield, Detroit, MI 48201, USA.

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