机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.放射科首都医科大学宣武医院[2]Department of Radiology – Medical Physics, University Hospital, Freiburg, Germany.[3]Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA.[4]Dept. of Microsystems Engineering, University of Freiburg, Germany.[5]Freiburg Institute for Advanced Studies (FRIAS), Freiburg, Germany. Parts of this work were presented at the Annual Meeting of the ISMRM, 2009.
Purpose: To assess blood flow velocities and spatial distribution of aortic Reynolds numbers in vivo using flow-sensitive magnetic resonance imaging (MRI) and probe for flow instabilities along the aorta based on an empirical model for physiological pulsatile blood flow. Materials and Methods: Thirty young healthy volunteers were examined by flow-sensitive MRI at eight imaging planes distributed along the thoracic aorta. Flow, Womersley, Strouhal, Reynolds, and critical Reynolds numbers were calculated and used to assess the presence of flow instabilities. Results: The average peak Reynolds number was higher in the ascending (approximate to 4500) and descending aorta (approximate to 4200) than in the aortic arch (approximate to 3400). According to the calculated critical Reynolds numbers, flow instabilities were prominent in the ascending (14/30 volunteers) and descending aorta (22/30 volunteers) but not in the aortic arch (3/30 volunteers). A significant difference (P < 0.05) in supracritical peak Reynolds numbers was observed between genders. The supracritical Reynolds number, indicating flow instabilities, significantly correlated (P < 0.05) with body weight (r = 0.34), aortic diameter (r = 0.48), and cardiac output (r = 0.53). Conclusion: Flow-sensitive MRI was used to indirectly assess the presence of flow instabilities in vivo. The results in volunteers indicate the presence of flow instabilities in the young healthy aorta with a higher prevalence for men than women.
基金：
EU Science & Technology Fellowship Program(Contract grant number: EuropeAid/127024/L/ACT/CN_STF/33)
Bundesministerium fu¨ r Bildung und Forschung (BMBF)(Contract grant number: 01EV0706)
第一作者机构：[1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.[2]Department of Radiology – Medical Physics, University Hospital, Freiburg, Germany.
通讯作者：
通讯机构：[*1]Xuanwu Hospital of Capital Medical University, Dept. of Radiology, N.45 Changchunjie, 100053 Beijing, China.
推荐引用方式(GB/T 7714)：
Aure′ lien F. Stalder,Alex Frydrychowicz,Max F. Russe,et al.Assessment of Flow Instabilities in the Healthy Aorta Using Flow-Sensitive MRI[J].JOURNAL OF MAGNETIC RESONANCE IMAGING.2011,33(4):839-846.doi:10.1002/jmri.22512.
APA：
Aure′ lien F. Stalder,Alex Frydrychowicz,Max F. Russe,Jan G. Korvink,Ju¨rgen Hennig...&and Michael Markl.(2011).Assessment of Flow Instabilities in the Healthy Aorta Using Flow-Sensitive MRI.JOURNAL OF MAGNETIC RESONANCE IMAGING,33,(4)
MLA：
Aure′ lien F. Stalder,et al."Assessment of Flow Instabilities in the Healthy Aorta Using Flow-Sensitive MRI".JOURNAL OF MAGNETIC RESONANCE IMAGING 33..4(2011):839-846
