机构：[1]Department of Neuroradiology, University Hospital Freiburg, Breisacher Strasse 64,79106, Freiburg, Germany[2]Institute of Radiology, University Hospital Basel, Basel, Switzerland[3]Department of Neurology, University Hospital Basel, Basel, Switzerland[4]Department of Radiological Physics, Institute of Radiology, University Hospital Basel,Basel, Switzerland[5]Department of Radiology, Xuanwu Hospital—Capital Medical University,Beijing, China放射科首都医科大学宣武医院[6]Departments of Radiology and Biomedical Engineering, Northwestern University Feinberg School of Medicine, Chicago, USA[7]Neuroradiology, Swiss Neuro Institute, Klinik Hirslanden, Zurich, Switzerland
4D phase contrast MR imaging (4D PC MRI) has been introduced for spatiotemporal evaluation of intracranial hemodynamics in various cerebrovascular diseases. However, it still lacks validation with standards of reference. Our goal was to compare blood flow quantification derived from 4D PC MRI with transcranial ultrasound and 2D PC MRI. Velocity measurements within large intracranial arteries [internal carotid artery (ICA), basilar artery (BA), and middle cerebral artery (MCA)] were obtained in 20 young healthy volunteers with 4D and 2D PC MRI, transcranial Doppler sonography (TCD), and transcranial color-coded duplex sonography (TCCD). Maximum velocities at peak systole (PSV) and end diastole (EDV) were compared using regression analysis and Bland-Altman plots. Correlation of 4D PC MRI measured velocities was higher in comparison with TCD (r = 0.49-0.66) than with TCCD (0.35-0.44) and 2D PC MRI (0.52-0.60). In mid-BA and ICA C7 segment, a significant correlation was found with TCD (0.68-0.81 and 0.65-0.71, respectively). No significant correlation was found in carotid siphon. On average over all volunteers, PSVs and EDVs in MCA were minimally underestimated compared with TCD/TCCD. Minimal overestimation of velocities was found compared to TCD in mid-BA and ICA C7 segment. 4D PC MRI appears as valid alternative for intracranial velocity measurement consistent with previous reference standards, foremost with TCD. Spatiotemporal averaging effects might contribute to vessel size-dependent mild underestimation of velocities in smaller (MCA), and overestimation in larger-sized (BA and ICA) arteries, respectively. Complete spatiotemporal flow analysis may be advantageous in anatomically complex regions (e.g. carotid siphon) relative to restrictions of ultrasound techniques.
基金：
the Swiss National Science Foundation (SNF 320000-113492/1)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
JCR分区：
出版当年[2011]版：
Q2CLINICAL NEUROLOGYQ2NEUROIMAGINGQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROIMAGING
第一作者机构：[1]Department of Neuroradiology, University Hospital Freiburg, Breisacher Strasse 64,79106, Freiburg, Germany
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neuroradiology, University Hospital Freiburg, Breisacher Strasse 64,79106, Freiburg, Germany
推荐引用方式(GB/T 7714)：
Stephan Meckel,Lorenz Leitner,Leo H. Bonati,et al.Intracranial artery velocity measurement using 4D PC MRI at 3 T: comparison with transcranial ultrasound techniques and 2D PC MRI[J].NEURORADIOLOGY.2013,55(4):389-398.doi:10.1007/s00234-012-1103-z.
APA：
Stephan Meckel,Lorenz Leitner,Leo H. Bonati,Francesco Santini,Tilman Schubert...&Stephan G. Wetzel.(2013).Intracranial artery velocity measurement using 4D PC MRI at 3 T: comparison with transcranial ultrasound techniques and 2D PC MRI.NEURORADIOLOGY,55,(4)
MLA：
Stephan Meckel,et al."Intracranial artery velocity measurement using 4D PC MRI at 3 T: comparison with transcranial ultrasound techniques and 2D PC MRI".NEURORADIOLOGY 55..4(2013):389-398
