机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China神经内科首都医科大学宣武医院[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, PR China
Inflammatory response is involved in the etiopathology of Alzheimer's disease (AD). Interleukin-6 (IL-6), a pleiotropic inflammatory cytokine, was reported to be associated with both increased A beta aggregation and the appearance of hyperphosphorylated tau in AD brain. To explore the association of genetic variants in the promoter of IL-6 gene with sporadic AD (SAD), a case-control study was conducted in a North Chinese Han population. A systematic screening of IL-6 promoter was performed using direct sequencing and two polymorphisms were obtained including -572C/G (rs1800796) and -384A/T (rs7802308). Definitive genotyping of these markers and apolipoprotein E (APOE) polymorphism were surveyed in 341 SAD patients and 421 controls. The results revealed no significant differences in the distributions of alleles or genotypes between SAD and control groups. However, there was an interaction between -572C/G and APOE genotypes (P = 0.016) using logistic analysis. In the subjects with APOE epsilon 4, there were significant differences in the allele (P = 0.004) and genotype (P = 0.004) distributions of -572C/G polymorphism between SAD and control groups. The -572CC genotype increased risk for AD by 3.301-fold (Wald = 11.093, adjust OR = 3.301, 95% CI = 1.635-6.665, P = 0.001) compared to CG + GG genotype. The present results suggest the -572 polymorphism could modify the risk for SAD in APOE epsilon 4 carriers. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
基金：
National Key Technology R&D Program in the Eleventh Five-Year Plan Period (2006BAI02B01), the Key Project of the National Natural Science Foundation of China (30830045),
the National Basic Research 973 Program (2006CB500700), Beijing Natural Science Foundation (7071004), the National Natural Science foundation of China (30600656),
the New-Star Plan of Science and Technology of Beijing (2004B12) and the Key Project of Science and Technology Plan of Beijing Municipal Education Commission (KZ200910025005).
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, PR China
通讯作者：
通讯机构：[*]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
推荐引用方式(GB/T 7714)：
Min Wang,Jianping Jia.The interleukin-6 gene-572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers[J].NEUROSCIENCE LETTERS.2010,482(3):260-263.doi:10.1016/j.neulet.2010.07.051.
APA：
Min Wang&Jianping Jia.(2010).The interleukin-6 gene-572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.NEUROSCIENCE LETTERS,482,(3)
MLA：
Min Wang,et al."The interleukin-6 gene-572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers".NEUROSCIENCE LETTERS 482..3(2010):260-263
