机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, PR China神经内科首都医科大学宣武医院[b]Key Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing 100053, PR China
Cerebral accumulation of amyloid beta protein (A beta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in A beta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han populations we found three polymorphisms in IDE promoter: -1002T/G (rs3758505), -179T/C (rs4646953) and -51C/T (rs4646954). The -1002T and -51C alleles were over-represented in 357 sporadic AD (SAD) patients when compared to those in 331 healthy individuals. Furthermore, -1002T/G and -51C/T were in strong linkage disequilibrium and they constructed a relatively risky -1002T/-51C and a relatively protective -1002G/-51T. Luciferase reporter assay indicated -1002T/-51C had lower transcriptional activity than -1002G/-51T. A more marked increase in -1002T/-51C transcriptional activity was seen when under A beta(25-35) and serum deprivation treatment. The present study provides evidence that IDE promoter polymorphisms that significantly decrease IDE expression levels are associated with development of SAD. (C) 2008 Published by Elsevier B.V.
基金：
National Key Technology R&D Program in the Eleventh Five-year Plan Period (2006BAI02B01), the National Basic Research 973 Program (2006CB500700),
the Beijing Natural Science Foundation (7071004), and the Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, PR China[b]Key Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing 100053, PR China
通讯作者：
通讯机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Xiumei Zuo,Jianping Jia.Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease[J].BRAIN RESEARCH.2009,1249:44934.doi:10.1016/j.brainres.2008.10.034.
APA：
Xiumei Zuo&Jianping Jia.(2009).Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.BRAIN RESEARCH,1249,
MLA：
Xiumei Zuo,et al."Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease".BRAIN RESEARCH 1249.(2009):44934
