机构：[1]Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China[2]PET Center of Xuan Wu Hospital, Beijing, China首都医科大学宣武医院[3]Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
As degradation product of Antineoplaston A10 in vivo, phenylacetyl glutamine showed antitumor activities. According to literatures, we designed and radiosynthesized a phenylacetyl glutamine derivative, which was achieved under a mild reaction condition. Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of (S)-2-((S)-2-(4-(3-fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid ([F-18]FBPPA) was 98%, and besides the best radiochemical yield was up to 46%. T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios of [F-18]FBPPA at 60 min post injection were 2.33 and 3.51. Meanwhile, it showed satisfied stability in vitro and in vivo, compared with 2-[F-18]fluorodeoxyglucose ([F-18]FDG). Although [F-18]FBPPA deserved further studies to make optimizations on its structure, the results revealed it might become a potential PET imaging agent for detecting tumors.
基金：
National Natural Science Foundation of China (No.20371009 and No.20671014), Key laboratory of Radioactive Medicine of Ministry Education and Beijing Municipal Commission of Education.
第一作者机构：[1]Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China
通讯作者：
通讯机构：[1]Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China
推荐引用方式(GB/T 7714)：
Yong He,Rui Ding,Hang Liu,et al.(S)-2-((S)-2-(4-(3-[F-18]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with F-18[J].JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY.2010,286(1):135-140.doi:10.1007/s10967-010-0633-2.
APA：
Yong He,Rui Ding,Hang Liu,Xiao Wang,Jing-Li Xu...&Yun-Chuan Ma.(2010).(S)-2-((S)-2-(4-(3-[F-18]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with F-18.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,286,(1)
MLA：
Yong He,et al."(S)-2-((S)-2-(4-(3-[F-18]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with F-18".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 286..1(2010):135-140
