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Synthesis and evaluation of novel F-18 labeled fluoroarylvaline derivatives: Potential PET imaging agents for tumor detection

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文献详情

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WOS体系：

收录情况： ◇ SCIE

作者：
Yali Qiao [a] * ; Yong He [a] ; Shuting Zhang [a] ; Guixia Li [a] ; Hang Liu [a] ; Jingli Xu [a] ; Xiao Wang [a] ; Chuanmin Qi [a] ; Cheng Peng [b] ;
机构： [a]Key laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, Beijing 100875, People’s Republic of China [b]Center of PET, Xuan Wu Hospital, Beijing 100053, People’s Republic of China
出处：
DOI： 10.1016/j.bmcl.2009.03.027
ISSN：

关键词： Amino acids F-18 labeled Fluoroarylvaline derivatives PET imaging agents Tumor detection

摘要：
Two F-18 labeled fluoroarylvaline derivatives, methyl 2-(2-[F-18]fluoro-4-nitrobenzamido)-3-methylbutanoate ([F-18]1, [F-18]MFNBMB) and its corresponding acid 2-(2-[F-18]fluoro-4-nitrobenzamido)-3-methylbutanoic acid ([F-18]2, [F-18]FNBMBA), have been designed and synthesized, respectively, by our team. Meanwhile, we research on their biodistributions in mice model bearing S 180 tumor. Furthermore, we also carried out the biological evaluations of 2-[F-18]fluorodeoxyglucose ([F-18]FDG) and O-2-[18F]fluoroethyl- L-tyrosine (L-[18F]FET) in the same model for comparison with our targeting molecules [F-18]1 and [F-18]2. Excitingly, the tumor/blood (T/Bl) and tumor/brain (T/Br) ratios were 2.91, 7.06 at 30 min, 3.44, 5.61 at 60 min post injection for [F-18]1, 2.32, 13.30 for [F-18]2 at 30 min post injection, which were obviously superior to [F-18] FDG and L-[F-18] FET in the same model and demonstrated that [F-18]1 and [F-18]2, especially [F-18]2, were potential PET imaging agents for tumor detection. (C) 2009 Elsevier Ltd. All rights reserved.

基金：
National Natural Science foundation of China (No. 20371009 and 20671014) and Beijing Key Subject Program
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2008]版：
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 有机化学
最新[2023]版：
大类 | 4 区 医学
小类 | 2 区 有机化学 4 区 药物化学
JCR分区：
出版当年[2007]版：
Q2 CHEMISTRY, ORGANIC Q2 CHEMISTRY, MEDICINAL
最新[2023]版：
Q2 CHEMISTRY, ORGANIC Q3 CHEMISTRY, MEDICINAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2007版] 出版当年五年平均 出版前一年[2006版] 出版后一年[2008版]

第一作者：
第一作者机构： [a]Key laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, Beijing 100875, People’s Republic of China
通讯作者：
通讯机构： [a]Key laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, Beijing 100875, People’s Republic of China
推荐引用方式(GB/T 7714)：
Yali Qiao,Yong He,Shuting Zhang,et al.Synthesis and evaluation of novel F-18 labeled fluoroarylvaline derivatives: Potential PET imaging agents for tumor detection[J].BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.2009,19(16):4873-4877.doi:10.1016/j.bmcl.2009.03.027.
APA：
Yali Qiao,Yong He,Shuting Zhang,Guixia Li,Hang Liu...&Cheng Peng.(2009).Synthesis and evaluation of novel F-18 labeled fluoroarylvaline derivatives: Potential PET imaging agents for tumor detection.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19,(16)
MLA：
Yali Qiao,et al."Synthesis and evaluation of novel F-18 labeled fluoroarylvaline derivatives: Potential PET imaging agents for tumor detection".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19..16(2009):4873-4877

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