机构：[a]Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, PR China[b]Beijing PET Center, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China首都医科大学宣武医院
This study reports the synthesis and characterization of N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl-4-[F-18]fluorobenzamide ([F-18]MPP3F). The total reaction time for [F-18]MPP3F, including final high-performance liquid chromatography purification, was about 3 h. Typical decay-corrected radiochemical yield was 18.4 +/- 3.1%. The radiochemical purity was >98%. Biodistribution in mice showed that [F-18]MPP3F is a potential brain imaging agent for positron emission tomography. The brain uptake of [F-18]MPP3F was 6.59 +/- 0.77% Injected Dose/g at 2 min post-injection time. A brain-to-blood ratio of 3.67 was reached at 15 min after injection. (C) 2009 Elsevier Ltd. All rights reserved.
基金：
Scientific Research Founda-tion for the Returned Overseas Chinese Scholars, State EducationMinistry, and partly by the National Natural Science Foundation ofChina I (2087 102O)
and Beijing Natural Science Foundation(2092018).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2008]版：
大类|3 区工程技术
小类|3 区核科学技术4 区无机化学与核化学4 区核医学
最新[2023]版：
大类|3 区工程技术
小类|2 区无机化学与核化学3 区核科学技术4 区核医学
JCR分区：
出版当年[2007]版：
Q2NUCLEAR SCIENCE & TECHNOLOGYQ3CHEMISTRY, INORGANIC & NUCLEARQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2NUCLEAR SCIENCE & TECHNOLOGYQ3CHEMISTRY, INORGANIC & NUCLEARQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
