机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, PR China神经内科首都医科大学宣武医院[b]Laboratory of Cerebrovascular Disease, Xuan wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, PR China首都医科大学宣武医院[c]Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, PR China.
The lysine-specific histone demethylase 1 (LSD1) is a chromatin modifying enzyme that specifically removes methyl groups from lysine 4 of histone 3 (H3-K4) and induces transcriptional repression However, limited knowledge exists, regarding the existence and significance of LSD1 in the brain We identified the distribution of LSD1 and H3-K4 mono-, di-, and tri-methylation in the brain of rats, respectively. The temporal and spatial distribution of LSD1 during ischemic brain injury was also explored. LSD1 immunoreactive cells were nucleus positive and were concentrated in the neurons of the hippocampus, cerebral cortex, striatum and amagdala. The distributions of H3-K4 mono-, di-, and tri-methylation exhibited exactly the same pattern as LSD1. LSD1 expression was induced both region and cell specifically after ischemic/perfusion, and complied with the two-peak mode of expression. These studies revealed a tightly regulated distribution for LSD1 in the brain of rats under ischemic insult, suggesting a critical role in neuron function. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society All rights reserved.
基金：
Chinese Postdoctoral Scientific Foundation (no. 20070410089)
第一作者机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, PR China
通讯作者：
通讯机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Yun-Zhou Zhang,Qing- Hong Zhang,Hong Ye,et al.Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia[J].NEUROSCIENCE RESEARCH.2010,68(1):66-72.doi:10.1016/j.neures.2010.06.002.
APA：
Yun-Zhou Zhang,Qing- Hong Zhang,Hong Ye,Yan Zhang,Yu-Min Luo...&Ying-Ying Su.(2010).Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia.NEUROSCIENCE RESEARCH,68,(1)
MLA：
Yun-Zhou Zhang,et al."Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia".NEUROSCIENCE RESEARCH 68..1(2010):66-72
