Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon 4 in Chinese
机构：[a]Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China神经内科老年医学科首都医科大学宣武医院[b]Key Laboratory for Neurodegenerative Diseases of Ministry of Education[c]Chinese National Human Genome Center Beijing, #707 Yongchang North Road, Beijing, 100176, China
There is compelling evidence indicating that reduction of high-density lipoprotein (HDL) level is associated with increased risk of Alzheimer's disease (AD). It is known that the levels of HDL are regulated by cholesteryl ester transfer protein (CETP) and several single nucleotide polymorphisms (SNPs) in the CETP gene have been shown to be associated with the levels of HDL. Therefore, it is assumed that the CETP gene is a reasonable candidate for modifying the susceptibility in AD. In the present study, we investigated the association of four CETP SNPs (D442C, L296Q, Taq1B and 1405V) with the risk for sporadic AD in Northern Han-Chinese. One hundred and seven AD cases and 115 age and gender-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), denaturing high performance liquid chromatography (DHPLC) and DNA sequencing. The frequency of DG genotype (P=0.035) or G allele (P=0.038) for the CETP (D442C) polymorphism was greater in control subjects than in AD patients. The age- and sex-adjusted odds radio for DG vs. DD genotype was 0.202 (95% CI 0.043-0.958, P=0.044). When the sample was stratified by APOE epsilon 4 carrier status, the same tendency (P=0.042 for DG genotype, P = 0.046 for G allele) was observed in the presence of APOE epsilon 4, but not in the absence of APOE epsilon 4 (P = 0.284 for DG genotype, P = 0.298 for G allele). However, these results became not statistically significant after correcting for multiple testing (Bonferroni) because of limited number of our sample. Our current results suggest that G allele of CETP D442G may have a potential protective effect against the development of AD, especially in APOE epsilon 4 carriers, in Northern Han-Chinese, possibly through regulating the HDL level in the brain. (c) 2007 Elsevier B.V. All rights reserved.
基金：
Ministry of Sciences and Technology (2006CB500701, 2002BA711A07-04, 2002BA711A10).
第一作者机构：[a]Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China[b]Key Laboratory for Neurodegenerative Diseases of Ministry of Education
通讯作者：
通讯机构：[*]Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Xuanwu Hospital of Capital Medical University, Changchun Street, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Da-Wei Chen,Jing-Fang Yang,Zhe Tang,et al.Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon 4 in Chinese[J].BRAIN RESEARCH.2008,1187(1):52-57.doi:10.1016/j.brainres.2007.10.054.
APA：
Da-Wei Chen,Jing-Fang Yang,Zhe Tang,Xiu-Min Dong,Xiu-Li Feng...&Piu Chan.(2008).Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon 4 in Chinese.BRAIN RESEARCH,1187,(1)
MLA：
Da-Wei Chen,et al."Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon 4 in Chinese".BRAIN RESEARCH 1187..1(2008):52-57
