机构：[a]Department of Neurology, the First Affiliated Hospital of Nanjing Medical University,Nanjing,[b]Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Sciences, Beijing老年医学科首都医科大学宣武医院[c]Key Laboratory of Neurodegeneration,Ministry of Education, P.R.China
It has been demonstrated that several types of adult stem cells have a common attribute of tropism for gliomas. In our study, we provided evidence that embryonic stem cell-derived embryoid body (EB) cells also exhibited a tropism for gliomas. Chemotaxis assays and organotypic hippocampal slice culture experiments showed that EB cells were attracted by the conditioned medium from C6 glioma cells and by C6 glioma cells deposited on the slice. Aggregate culture assays showed that EB cells could coaggregate with C6 glioma cells. Embryoid body cells injected intratumorally were found to distribute throughout the tumor mass. All data indicated that EB cells displayed a tropism for gliomas.
基金：
National 973 Project grant of China (2006 CB 943703).
第一作者机构：[a]Department of Neurology, the First Affiliated Hospital of Nanjing Medical University,Nanjing,
通讯作者：
通讯机构：[*1]Department of Neurology, the First A?liated Hospital of NanjingMedical University, No. 300,Guangzhou Street,Nanjing, Jiangsu Province 210029, P.R.China[*2]Beijing Institute of Geriatrics, Xuanwu Hospital,Capital University ofMedical Sciences,No.45,Changchun Street, Beijing100053, P.R.China
推荐引用方式(GB/T 7714)：
Xiao-Bo Li,Yun-Qian Guan,Ping Ren,et al.The tropism of embryoid body cells for glioma cells[J].NEUROREPORT.2007,18(17):1821-1825.doi:10.1097/WNR.0b013e3282f13e30.
APA：
Xiao-Bo Li,Yun-Qian Guan,Ping Ren,Wan-Wan Zhu,Yang Wang...&Y. Alex Zhang.(2007).The tropism of embryoid body cells for glioma cells.NEUROREPORT,18,(17)
MLA：
Xiao-Bo Li,et al."The tropism of embryoid body cells for glioma cells".NEUROREPORT 18..17(2007):1821-1825
