机构：[a]Beijing Institute of Geriatrics, Department of Neurology, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing 100053, China神经内科老年医学科首都医科大学宣武医院[b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China[c]Department of Radiology, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing, China放射科首都医科大学宣武医院[d]Key Laboratory on Neurodegenerate Disorder of Ministry of Education, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing, China首都医科大学宣武医院
Our knowledge about aging modulation of the central motor system remains sparse and contradictory. In the current study, we used functional MRI (fMRI) to study the aging influence on regional homogeneity of the motor-related brain areas in the resting state. We found that regional hornogeneity in extensive motor regions, like the cingulate motor area, cerebellum, primary motor cortex, premotor area, supplementary motor area, thalamus, globus pallidus and putamen was significantly decreased in aged subjects. Our study indicates that normal aging process may disrupt the function of motor areas in the resting state, which may contribute to the declined motor ability in aged population. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
基金：
National Science Foundation of China, Grant No. 30570530, and grant from Ministry of Sciences and Technology (2006CB500701).
第一作者机构：[a]Beijing Institute of Geriatrics, Department of Neurology, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing 100053, China[d]Key Laboratory on Neurodegenerate Disorder of Ministry of Education, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing, China
通讯作者：
通讯机构：[a]Beijing Institute of Geriatrics, Department of Neurology, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Tao Wu,Yufeng Zang,Liang Wang,et al.Normal aging decreases regional homogeneity of the motor areas in the resting state[J].NEUROSCIENCE LETTERS.2007,423(3):189-193.doi:10.1016/j.neulet.2007.06.057.
APA：
Tao Wu,Yufeng Zang,Liang Wang,Xiangyu Long,Kuncheng Li&Piu Chan.(2007).Normal aging decreases regional homogeneity of the motor areas in the resting state.NEUROSCIENCE LETTERS,423,(3)
MLA：
Tao Wu,et al."Normal aging decreases regional homogeneity of the motor areas in the resting state".NEUROSCIENCE LETTERS 423..3(2007):189-193
