机构：[a]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China[b]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院[c]McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada[d]Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Resting-state functional magnetic resonance imaging (fMRI), a promising technique for measuring brain activities during rest, has attracted much attention in the past few years. In this paper, we review recent progress on the study of Alzheimer's disease (AD) based on resting-state fMRI. First, we briefly introduce some AD-related studies from other groups. Then we describe our AD-related work in detail from three aspects: (1) alterations in regional homogeneity (ReHo) of the fMRI signal in the resting state, (2) altered patterns of functional connectivity from regions of interest and whole brain analyses, and (3) discriminative analyses based on classification features from resting-state fMRI data for differentiating AD patients from healthy elders. Finally, we summarize the main results and some prospects for future work. (c) 2008 Published by Elsevier Ltd.
基金：
Natural Science Foundation of China, Grant Nos. 30425004 and 30730035, and the National Key Basic Research and Development Program (973), Grant No. 2004CB318107.
第一作者机构：[a]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
通讯作者：
通讯机构：[a]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
推荐引用方式(GB/T 7714)：
Yong Liu,Kun Wang,Chunshui YU,et al.Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: A review of resting-state fMRI studies[J].NEUROPSYCHOLOGIA.2008,46(6):1648-1656.doi:10.1016/j.neuropsychologia.2008.01.027.
APA：
Yong Liu,Kun Wang,Chunshui YU,Yong He,Yuan Zhou...&Tianzi Jiang.(2008).Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: A review of resting-state fMRI studies.NEUROPSYCHOLOGIA,46,(6)
MLA：
Yong Liu,et al."Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: A review of resting-state fMRI studies".NEUROPSYCHOLOGIA 46..6(2008):1648-1656
