机构：[a]Hefei National Laboratory for Physical Science at the Microscale, University of Science and Technology of China, Hefei 230026, PR China[b]Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei 230026, PR China[c]Xuanwu Hospital, Capital University of Medical Science, Beijing 100053, China首都医科大学宣武医院
Alzheimer's disease (AD) is the most prevalent cause of dementia in human beings. Its best-known pathologic feature is the presence of senile plaques and neurofibrillary tangles in the brain. Nogo-66 receptor (NgR) is believed to contribute to the inhibitory activities of axon regeneration after injury. This study investigated the expression of NgR in the hippocampus and its relation to the pathologic changes of AD using immunohistochemistry and double-labeling immunofluorescence methods. The results showed that NgR immunoreactivity was present in more than 50% of the pyramidal layer cells of the CA1 to CA4 subfields of the hippocampus. No significant difference was observed in the number of NgR immunopositive cells in the CA1 to CA4 subfields between patients with AD and control subjects, whereas the ratio of NgR immunopositive cells to the total number of pyramidal layer cells was revealed to be significantly higher in the CA1 and CA2 subfields of the hippocampus of patients with AD than that in the same region of the control subjects. Moreover, high numbers of AT-8 immunopositive cells were found to be double-labeled with NgR in the CAI subfields of patients with AD, whereas only few NgR deposits were observed in the senile plaques of the hippocampus in these patients. These results suggest that NgR may be related to the formation of tangles in AD. (c) 2007 Elsevier Inc. All rights reserved.
基金：
the Ministry of Science and Technology of China (grant no. 2006CB50705) and the Chinese Academy of Sciences (grant no. KSCXZ-SW-217).
第一作者机构：[a]Hefei National Laboratory for Physical Science at the Microscale, University of Science and Technology of China, Hefei 230026, PR China[b]Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei 230026, PR China
通讯作者：
通讯机构：[b]Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei 230026, PR China
推荐引用方式(GB/T 7714)：
Hong-Yan Zhu,Hou-Fu Guo,Hai-Long Hou,et al.Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease[J].HUMAN PATHOLOGY.2007,38(3):426-434.doi:10.1016/j.humpath.2006.09.010.
APA：
Hong-Yan Zhu,Hou-Fu Guo,Hai-Long Hou,Ya-Jing Liu,Shu-Li Sheng&Jiang-Ning Zhou.(2007).Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease.HUMAN PATHOLOGY,38,(3)
MLA：
Hong-Yan Zhu,et al."Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease".HUMAN PATHOLOGY 38..3(2007):426-434
