机构:[1]Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, People’s Republic of China[2]Department of Functional Neurosurgery, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, People’s Republic of China神经外科首都医科大学宣武医院[3]Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, People’s Republic of China神经内科首都医科大学宣武医院
The quality of life of many epilepsy patients may be improved significantly if the occurrence of epileptic seizures can be successfully forecasted and clinical intervention, such as electrical stimulation or drug delivery, can then be used to suppress their emergence, or warn the patient of the forthcoming events. In this paper, a prediction algorithm based on the second-order complexity measure was proposed to predict the impending seizures. Through the analysis of long-term intracranial EEG recordings from two frontal lobe epilepsy patients, the results indicated that the sensitivity of prediction was 77.8% (14/18) and 66.7% (4/6) and the number of false warnings was 3 and 2 for the two patients, respectively. Because only the information of past seizures was utilized to predict the current seizure and the computation load was low, the prediction algorithm could possibly be applied to clinical practice.
基金:
the Specialized Research Fund for the Doctoral Program of Higher Education (no 20020003031),
NSFC-RGC joint research grant (no 60318001)
the Key Project of Chinese Ministry of Education (no 1041185).