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A novel neurotrophic peptide: APP(63-73)

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机构： [1]Capital Univ Med Sci, Beijing Xuan Wu Hosp, Neurobiochem Lab, Beijing 100053, Peoples R China [2]Montclair State Univ, Dept Chem & Biochem, Montclair, NJ 07043 USA

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关键词： amyloid precursor protein APP(63-73) diabetes estrogen neurotrophic effect

摘要：

The objective of this study was to find out which N-terminal segment/s of amyloid precursor protein (APP) has any neurotrophic properties, since soluble APP-alpha (sAPP-alpha) has neurotrophic effects. We investigated neurotrophic properties of eight peptide segments of N-terminal APP. The APP(63-73) was able to enhance neuronal growth; augment axonal and cell body growth in human neuroblastoma cell line. SH-SY5Y Neurotrophic effects of chronic APP(63-73) treatment were assessed in vivo using streptozotocin-induced diabetes and ovariectomized rats, Thus, this study demonstrated that APP(63-73) peptide has neurotrophic effects both in vivo and in vitro.

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大类 | 4 区医学

小类 | 4 区神经科学

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Q2 NEUROSCIENCES

最新[2023]版：

Q4 NEUROSCIENCES

影响因子： 1.6 最新[2023版] 1.6 最新五年平均 2.265 出版当年[2002版] 0 出版当年五年平均 2.374 出版前一年[2001版] 2.503 出版后一年[2003版]

第一作者：

第一作者机构： [1]Capital Univ Med Sci, Beijing Xuan Wu Hosp, Neurobiochem Lab, Beijing 100053, Peoples R China [2]Montclair State Univ, Dept Chem & Biochem, Montclair, NJ 07043 USA

通讯作者：

通讯机构： [1]Capital Univ Med Sci, Beijing Xuan Wu Hosp, Neurobiochem Lab, Beijing 100053, Peoples R China

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