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CSF CHOLINESTERASE IN EARLY-ONSET AND LATE-ONSET ALZHEIMERS-DISEASE AND MULTIINFARCT DEMENTIA OF CHINESE PATIENTS

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收录情况： ◇ SCIE

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机构： [1]Dementia Study Group, Department of Neurology, Xuan Wu Hospital, Beijing, China [2]Department of Pharmacology, Oxford University, Mansfield Road, OX1 3QT, England

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关键词： DEMENTIA OF ALZHEIMER TYPE (DAT) EARLY ONSET LATE ONSET MULTI-INFARCT-DEMENTIA (MID) CHOLINESTERASE (CHE) CSF

摘要：

Using Ellman spectrophotometric method we measured the total cholinesterase (ChE) activity in lumbar cerebrospinal fluid (CSF) of 13 persons without neurological disorder, 10 non-demented patients with cerebral infarcts, 17 patients with dementia of Alzheimer's type (DAT) (11 presenile, 6 senile cases), 10 patients with multi-infarct dementia (MID), 1 patient with Parkinson's disease associated with dementia. The ChE activity in CSF was significantly lower in the DAT group compared with age-matched control subjects (p<0.001). This paper also analyses the possibility of using CSF ChE activity as a marker of DAT, and the relationships between its level of activity and the age of the patient at onset, stage of illness and severity of dementia as well as discrepancies in the data published so far. Previous work has shown that ChE activity in the brain tissue and CSF of MID is normal: therefore, if low ChE activity is found in the CSF of MID patients, as was obtained in 8 out of 10 cases in our series, the diagnosis of mixed dementia should be considered.

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最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学

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出版当年[1991]版：

无

最新[2023]版：

Q2 CLINICAL NEUROLOGY

影响因子： 2.9 最新[2023版] 3 最新五年平均 0 出版当年[1991版] 0 出版当年五年平均 0 出版前一年[1990版]

第一作者：

第一作者机构： [1]Dementia Study Group, Department of Neurology, Xuan Wu Hospital, Beijing, China [2]Department of Pharmacology, Oxford University, Mansfield Road, OX1 3QT, England

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