Objective: To study the clinical symptoms, diagnosis and treatment of eosinophilic gastroenteritis (EG). Methods: A total of 44 cases of EG admitted to our hospital were studied respectively in clinical manifestations, laboratory examinations, endoscopic signs and treatment. Results: (1) The presenting symptoms of EG patients was abdominal pain. (2) The endoscopic signs of EG were mucosal pathological changes of hyperemia, erosion and hyperplasia. A certain number of eosinophilic granulocytes were detected in pathological examination. (3) The hormones were effective and had quick onsets. While, based on different clinical symptoms, the traditional medicine was dosed by oral administration and intestinal enema. In TCM group (n = 22), 20 patients had a relief of clinical symptoms, 4 cases of recurrence and 16 of cure. In comparison, in hormone group (n = 18), 17 patients had a relief of clinical symptoms, 6 cases of recurrence and 12 of cure. The results showed that two groups had no statistical difference in relief of clinical symptoms, recurrence and hormonal cure (all P > 0.05). But it will be more readily accepted. Conclusions: The incidence of EG is low in clinical practice because of its non-specific clinical and endoscopic manifestations. An elevated count of eosinophilic graunlocytes in peripheral blood, ascitic fluid and tissues of mucous membrane are key diagnostic points. The hormonal treatment is both fast and effective. But traditional medicine will have a brighter clinical prospect. Copyright © 2012 by the Chinese Medical Association.