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Myelin Oligodendrocyte Glycoprotein-IgG Contributes to Oligodendrocytopathy in the Presence of Complement, Distinct from Astrocytopathy Induced by AQP4-IgG

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

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机构： [1]Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China [2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [3]Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Life Sciences, Shaanxi Normal University, Xi’an 710119, China [4]Department of Neurology, Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, Sir Charles Gairdner Hospital, University of Western Australia, Perth, WA 6009, Australia

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关键词： Aquaporin-4 immunoglobulin G Complement-dependent cytotoxicity Myelin oligodendrocyte glycoprotein immunoglobulin G Neuromyelitis optica spectrum disorder Transmission electron microscopy

摘要：

Immunoglobulin G against myelin oligodendrocyte glycoprotein (MOG-IgG) is detectable in neuromyelitis optica spectrum disorder (NMOSD) without aquaporin-4 IgG (AQP4-IgG), but its pathogenicity remains unclear. In this study, we explored the pathogenic mechanisms of MOG-IgG in vitro and in vivo and compared them with those of AQP4-IgG. MOG-IgG-positive serum induced complement activation and cell death in human embryonic kidney (HEK)-293T cells transfected with human MOG. In C57BL/6 mice and Sprague-Dawley rats, MOG-IgG only caused lesions in the presence of complement. Interestingly, AQP4-IgG induced astroglial damage, while MOG-IgG mainly caused myelin loss. MOG-IgG also induced astrocyte damage in mouse brains in the presence of complement. Importantly, we also observed ultrastructural changes induced by MOG-IgG and AQP4-IgG. These findings suggest that MOG-IgG directly mediates cell death by activating complement in vitro and producing NMOSD-like lesions in vivo. AQP4-IgG directly targets astrocytes, while MOG-IgG mainly damages oligodendrocytes. ? 2019, Shanghai Institutes for Biological Sciences, CAS.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 4 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区神经科学

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出版当年[2017]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.9 最新[2023版] 5.4 最新五年平均 3.155 出版当年[2017版] 2.834 出版当年五年平均 2.624 出版前一年[2016版] 4.246 出版后一年[2018版]

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第一作者机构： [1]Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China

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通讯机构： [1]Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China

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