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Contrast Staining may be Associated with Intracerebral Hemorrhage but Not Functional Outcome in Acute Ischemic Stroke Patients Treated with Endovascular Thrombectomy

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. [3]Department of Rehabilitation, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [4]Wayne State University School of Medicine, Detroit, MI, USA. [5]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA. [6]Department of Anesthesiology, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Massachusetts, USA. [7]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China. [8]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： post-interventional contrast staining endovascular thrombectomy outcome intracerebral hemorrhage

摘要：

To evaluate the incidence of post-interventional contrast staining (PICS) in acute ischemic stroke (AIS) Chinese patients who were treated with endovascular thrombectomy (ET) and investigate potential association of PICS with functional outcome and intracerebral hemorrhage (ICH). This observational study was based on a single-center prospective registry study. AIS patients who underwent ET from January 2013 to February 2017 were recruited into this study. All patients had dual-energy CT (DECT) scan of the head at 12 to 24 hours post-ET. The primary outcome was the incidence of PICS. Secondary outcomes were total ICH, symptomatic ICH (sICH), 3-month functional outcome, and long-term functional outcome. One hundred and eighty patients were enrolled in this study. PICS was detected in 50 patients (28%) based on the post-interventional CT scan. We first used basic statistical analyses, showing that the incidence of both total ICH (60% vs. 25%, p< 0.001) and sICH (18% vs. 8%, p=0.044) were higher in patients with PICS than those without, and fewer patients achieved no disability (mRS <= 1) in the PICS group compared to the control group at both 3-month and long-term follow-up (p< 0.01 each). However, multivariate regression analysis further revealed that PICS only increased total (adjusted odds ratio, 7.38; 95% confidence interval 1.66 to 32.9; p=0.009) but not sICH risk. Furthermore, the logistic regression analyses did not show statistical difference in good clinical outcomes or mortality between the two groups. PICS is a common phenomenon in Chinese AIS patients. It is associated with total ICH after ET, but it seems to have no effect on functional outcome and sICH. Further large-scale studies are warranted to validate these results.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 2 区老年医学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区老年医学

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出版当年[2017]版：

Q1 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY

影响因子： 7 最新[2023版] 7.1 最新五年平均 5.058 出版当年[2017版] 4.69 出版当年五年平均 4.648 出版前一年[2016版] 4.232 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.

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通讯作者：

通讯机构： [2]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. [8]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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Contrast Staining may be Associated with Intracerebral Hemorrhage but Not Functional Outcome in Acute Ischemic Stroke Patients Treated with Endovascular Thrombectomy

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