个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Low-dose tirofiban is associated with reduced in-hospital mortality in cardioembolic stroke patients treated with endovascular thrombectomy.

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wenbo Zhao[a,b,c,*1] * ; Jiali Xu[a] * ; Sijie Li[c] ; Guiyou Liu[b] ; Longfei Wu[a] ; Chuanhui Li[d] ; Chuanjie Wu[a] ; Changhong Ren[b] ; Jian Chen[e] ; Jiangang Duan[f] ; Ruixian Wang[g] ; Haiqing Song[a] ; Qingfeng Ma[a,d] ; Xunming Ji[b,e,*2] ;
机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [c]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [d]Clinical Stroke Research Unit, Xuanwu Hospital, Capital Medical University, Beijing, China [e]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [f]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China [g]Department of Neurology, Tianjin Beichen Traditional Chinese Medicine Hospital, Tianjin, China
出处：
DOI： 10.1016/j.jns.2021.117539
ISSN：

关键词： Cardioembolic stroke Endovascular thrombectomy Tirofiban Intracerebral hemorrhage

摘要：
Whether tirofiban is safe and effective in cardioembolic stroke patients treated with endovascular thrombectomy (EVT) remains unknown; this study evaluated the safety and efficacy of low-dose tirofiban in this patients population.This study was a prospective registry study. Patients with cardioembolic stroke undergoing EVT from January 2013 to December 2020 were treated with EVT alone or EVT plus low-dose tirofiban. The primary outcome was symptomatic intracerebral hemorrhage (sICH) prior to discharge. The secondary outcomes included reocclusion, in-hospital mortality, and 3-month functional outcomes.Overall, 288 patients were recruited and 117 received low-dose tirofiban; 137 patients (47.6%) experienced ICH, 42 patients (14.6%) were sICH, and 23 patients (8%) were fatal ICH. Thirteen patients (11.1%) receiving tirofiban and 29 patients (17.0%) not receiving tirofiban experienced sICH (p = 0.167). Reocclusion occurred in nine patients (7.7%) receiving tirofiban and 15 patients (8.8%) not receiving tirofiban (p = 0.745). The rates of hernia (6.8% versus 20.5%) and decompressive craniectomy (2.6% versus 11.7%) were significantly lower in patients receiving tirofiban (p < 0.01). At 3-month follow-up, functional independence was achieved in 39 patients(33.3%) receiving tirofiban and 43 patients (25.1%) not receiving tirofiban (p = 0.131). Tirofiban was associated with lower odds of in-hospital mortality (3.4% versus 12.3%; adjusted odds ratio, 0.16; 95% confidence interval, 0.03-0.81; adjusted p = 0.027).In patients with cardioembolic stroke undergoing EVT, tirofiban is not associated with higher sICH, it seems to lead to lower odds of in-hospital death. Further investigations are needed to confirm these results and to determine the optimal treatment protocols of tirofiban.Copyright © 2021. Published by Elsevier B.V.

基金：
This study was supported by Beijing Nova Program (No. Z201100006820143), General Project of Science and Technology of Beijing Municipal Education Commission (No. KM202110025018), National Natural Science Foundation of China (No. 82001257, 82027802, and 81620108011), and Beijing Hundred Thousand and Ten Thousand Talent Project (No. 2019A36).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 4 区 神经科学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
JCR分区：
出版当年[2019]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [c]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [c]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [e]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China. [*2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Wenbo Zhao,Jiali Xu,Sijie Li,et al.Low-dose tirofiban is associated with reduced in-hospital mortality in cardioembolic stroke patients treated with endovascular thrombectomy.[J].JOURNAL OF THE NEUROLOGICAL SCIENCES.2021,427:doi:10.1016/j.jns.2021.117539.
APA：
Wenbo Zhao,Jiali Xu,Sijie Li,Guiyou Liu,Longfei Wu...&Xunming Ji.(2021).Low-dose tirofiban is associated with reduced in-hospital mortality in cardioembolic stroke patients treated with endovascular thrombectomy..JOURNAL OF THE NEUROLOGICAL SCIENCES,427,
MLA：
Wenbo Zhao,et al."Low-dose tirofiban is associated with reduced in-hospital mortality in cardioembolic stroke patients treated with endovascular thrombectomy.".JOURNAL OF THE NEUROLOGICAL SCIENCES 427.(2021)

相关文献

[1]Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy [2]Unfavorable Outcome of Thrombolysis in Chinese Patients with Cardioembolic Stroke: a Prospective Cohort Study [3]Asymptomatic Intracerebral Hemorrhage May Worsen Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy [4]Contrast Staining may be Associated with Intracerebral Hemorrhage but Not Functional Outcome in Acute Ischemic Stroke Patients Treated with Endovascular Thrombectomy [5]Contrast Staining may be Associated with Intracerebral Hemorrhage but Not Functional Outcome in Acute Ischemic Stroke Patients Treated with Endovascular Thrombectomy [6]The impact of intraarterial, intravenous, and combined tirofiban on endovascular treatment for acute intracranial atherosclerotic occlusion [7]The max-intracerebral hemorrhage score predicts long-term outcome of intracerebral hemorrhage [8]CORM-2 inhibits intracerebral hemorrhage-mediated inflammation [9]Noncoding RNAs and Intracerebral Hemorrhage [10]CADASIL: two new cases with intracerebral hemorrhage

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院