机构：[1]Department of Neonatal Intensive Care Unit, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310053, China[2]Department of Neonatology, Anhui Provincial Hospital, Hefei, Anhui 230001, China[3]Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China[4]Department of Neonatology, BaYi Children’s Hospital of the General Military Hospital of Beijing People’s Liberation Army, Beijing 100000, China[5]Department of Neonatology, Children’s Hospital of Fudan University, Shanghai 200032, China[6]Department of Neonatology, Gansu Provincial Maternity and Children‑care Hospital, Lanzhou, Gansu 730050, China[7]Department of Neonatology, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou 550003, China[8]Department of Neonatology, Women and Children Hospital of Guangdong Province, Guangzhou, Guangdong 510010, China[9]Department of Neonatology, Guangxi Maternal and Child Health Hospital, Nanning, Guangxi 530003, China[10]Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China[11]Department of Neonatology, Harbin Children’s Hospital, Harbin, Heilongjiang 150010, China[12]Department of Neonatology, Children’s Hospital of Hebei Province, Shijiazhuang, Hebei 050031, China[13]Department of Neonatology, Hunan Children’s Hospital, Changsha, Hunan 410007, China[14]Department of Neonatology, Hubei Maternity and Child Heath Hospital, Wuhan, Hubei 430070, China[15]Department of Pediatrics, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China其他科室儿科华中科技大学同济医学院附属同济医院[16]Department of Neonatology, The First Hospital of Jilin University, Changchun, Jilin 130021, China[17]Department of Neonatology, Jiangxi Provincial Children’s Hospital, Nanchang, Jiangxi 330006, China[18]Department of Pediatric, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China昆明医科大学附属第一医院[19]Department of Neonatology, Nanjing Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu 320100, China[20]Department of Neonatology, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, China[21]Department of Neonatal Intensive Care Unit, Ningbo Women and Children’s Hospital, Ningbo, Zhejiang 315012, China[22]Department of Neonatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China[23]Department of Neonatology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China[24]Department of Neonatology, Quanzhou Women’s and Children’s Hospital, Quanzhou, Fujian 362000, China[25]Department of Neonatology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 710068, China[26]Department of Neonatology, Shenzhen Children’s Hospital, Shenzhen, Guangdong 518026, China[27]Department of Neonatology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China临床科室新生儿中心首都医科大学附属北京儿童医院[28]Department of Neonatology, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China[29]Department of Neonatology, The First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China[30]Department of Neonatology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China临床科室新生儿科浙江大学医学院附属妇产科医院[31]Department of Neonatology, Zhengzhou Children’s Hospital, Zhengzhou, Henan 450007, China[32]Department of Neonatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China[33]Department of Neonatology, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, China
Background: With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. Methods: All infants admitted to 26 NICUs with a birth weight (BW) < l000 g were included between January l, 2011 and December 31, 2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results: A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age (GA) was 28.1 2.2 weeks, and the mean BW was 868 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants (23.3%) died and another 69 infants (26.7%) died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas (53.6% vs. 35.3%, P = 0.019). BW < 750 g and GA < 28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions: Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.
基金：
National Key Technology Research and Development ProgramNational Key Technology R&D Program [2012BAI04B04]; Zhejiang Province Ministry of Education [Y200908620]
第一作者机构：[1]Department of Neonatal Intensive Care Unit, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310053, China
通讯作者：
通讯机构：[*1]Department of Neonatal Intensive Care Unit, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310051, China
推荐引用方式(GB/T 7714)：
Hui‑Jia Lin,Li‑Zhong Du,Xiao‑Lu Ma,et al.Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study[J].CHINESE MEDICAL JOURNAL.2015,128(20):2743-2750.doi:10.4103/0366-6999.167312.
APA：
Hui‑Jia Lin,Li‑Zhong Du,Xiao‑Lu Ma,Li‑Ping Shi,Jia‑Hua Pan...&Si‑Qi Zhuang.(2015).Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study.CHINESE MEDICAL JOURNAL,128,(20)
MLA：
Hui‑Jia Lin,et al."Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study".CHINESE MEDICAL JOURNAL 128..20(2015):2743-2750
