机构：[1]Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室眼科首都医科大学附属安贞医院[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属同仁医院[3]Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China首都医科大学附属同仁医院[4]Astronaut Research and Training Center of China, Beijing, China航天员中心
Objective: To investigate the effects of hypergravity on retinal structure in rat. Methods: Retinal structure and protein expression were examined by hematoxylin and eosin stain, immunohistochemistry and Western blot in the Sprague-Dawley (R) rats induced by hypergravity with short arm centrifuge (+ 10 Gz/3 min). Results: Retinal structure had no substantial change after hypergravity stimulation, but the expression levels of glial fibrillary acidic protein and ciliary neurotrophic factor were significantly increased by hypergravity stimulation. Conclusion: Hypergravity induced the expression levels of ciliary neurotrophic factor, which protect retinal structure against hypergravity stimulation with short time and high +Gz value in rat.
第一作者机构：[1]Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[3]Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China
通讯作者：
通讯机构：[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[3]Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China[4]Astronaut Research and Training Center of China, Beijing, China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China[*2]Astronaut Research and Training Center of China, Beijing 100094, China
推荐引用方式(GB/T 7714)：
Jia Guo,Xiao Li,Yang Zhao,et al.Ciliary neurotrophic factor protects retinal structure against hypergravity stimulation with short time and high plus Gz value in rat[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2017,10(3):3653-3661.
APA：
Jia Guo,Xiao Li,Yang Zhao,Ping Wu,Xiaoping Chen&Siquan Zhu.(2017).Ciliary neurotrophic factor protects retinal structure against hypergravity stimulation with short time and high plus Gz value in rat.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,10,(3)
MLA：
Jia Guo,et al."Ciliary neurotrophic factor protects retinal structure against hypergravity stimulation with short time and high plus Gz value in rat".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 10..3(2017):3653-3661
