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Investigating the regulation mechanism of baicalin on triple negative breast cancer's biological network by a systematic biological strategy.

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资源类型：

收录情况： ◇ SCIE

作者：
Kailin Yang[a,b] * ; Liuting Zeng[c] * ; Anqi Ge[d] * ; Zhouhua Chen[e] ; Tingting Bao[f] ; Zhiyong Long[g] ; Jinwen Ge[c] ; Lizhong Huang[c] ;
机构： [a]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing [b]Capital Medical University, Beijing, China [c]Hunan University of Chinese Medicine, Changsha, Hunan Province, China [d]The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province, China [e]The Second People's Hospital of Xiangtan City, Xiangtan, Hunan Province, China [f]Beijing University of Chinese Medicine, Beijing, China [g]Shantou University Medical College, Shantou, Guangdong Province, China
出处：
DOI： 10.1016/j.biopha.2019.109253
ISSN：

关键词： Baicalin MDA-MB-231 cell Real-time quantitative PCR Systematic biology Triple negative breast cancer

摘要：
To investigate the regulation mechanism of baicalin on triple negative breast cancer (TNBC)'s biological network by a systematic biological strategy and cytology experiment. A systematic biological methodology is utilized to predict the potential targets of baicalin, collect the genes of TNBC, and analyze the TNBC and baicalin's network. After the systematic biological analysis is performed, the cytology experiment, real-time quantitative PCR (qPCR) is used to validate the key biological processes and signaling pathways. After systematic biological analysis, two networks were constructed and analyzed: (1) TNBC network; (2) Baicalin-TNBC protein-protein interaction (PPI) network. Several TNBC-related, treatment-related targets, clusters, signaling pathways and biological processes were found. Cytology experiment shows that baicalin can inhibit the proliferation, migration and invasion of breast cancer MDA-MB-231 cells in vitro (P < 0.05). The results of qPCR showed that baicalin increase the expression of E-cadherin mRNA, and decrease the expression of vimentin, β-catenin, c-Myc and MMP-7 mRNA in LPS-induced breast cancer MDA-MB-231 cells (P < 0.05). Baicalin may achieve anti-tumor effects through regulating the targets, biological processes and pathways found in this research. Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

基金：
This work is supported by the Scientific Research Fund of Hunan Provincial Education Department (No. 12C1205 ), the Hunan Provincial Natural Science Foundation of China (No. 2015JJ6080 ), the Key Project of Hunan Provincial Education Department (No. 15A139 ), the National Natural Science Foundation of China (No. 81274008 ).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 药学 2 区 医学：研究与实验
JCR分区：
出版当年[2017]版：
Q2 PHARMACOLOGY & PHARMACY Q2 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing [b]Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [c]Hunan University of Chinese Medicine, Changsha, Hunan Province, China
推荐引用方式(GB/T 7714)：
Kailin Yang,Liuting Zeng,Anqi Ge,et al.Investigating the regulation mechanism of baicalin on triple negative breast cancer's biological network by a systematic biological strategy.[J].BIOMEDICINE & PHARMACOTHERAPY.2019,118:109253.doi:10.1016/j.biopha.2019.109253.
APA：
Kailin Yang,Liuting Zeng,Anqi Ge,Zhouhua Chen,Tingting Bao...&Lizhong Huang.(2019).Investigating the regulation mechanism of baicalin on triple negative breast cancer's biological network by a systematic biological strategy..BIOMEDICINE & PHARMACOTHERAPY,118,
MLA：
Kailin Yang,et al."Investigating the regulation mechanism of baicalin on triple negative breast cancer's biological network by a systematic biological strategy.".BIOMEDICINE & PHARMACOTHERAPY 118.(2019):109253

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