详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA [2]Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, China [3]Department of Anesthesiology, Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, China [4]Department of Anesthesiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, China [5]Department of Anesthesiology, Beijing Children’s Hospital, Beijing 100045, China

出处：

DOI：

ISSN：

关键词： Brain-derived neurotrophic factor Enriched environment Neurogenesis Postoperative cognitive dysfunction

摘要：

Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neurogenesis contributes to cognition. It is known that enriched environment (EE) enhances neurogenesis. We determined whether EE attenuated surgery-induced cognitive impairment and whether growth factors and neurogenesis played a role in the EE effect. Eight-week-old C57BL/6J mice were subjected to carotid artery exposure. Their learning and memory were assessed by Barnes maze, and fear conditioning started 2 weeks after the surgery. Growth factor expression and cell genesis were determined at various times after the surgery. Surgery increased the time for the mice to identify the target hole in the Barnes maze and reduced context-related freezing behavior. Surgery also reduced the expression of brain-derived neurotrophic factor (BDNF) and neurogenesis in the hippocampus. These effects were attenuated by EE. EE also attenuated surgery-induced reduction of phosphorylated/activated tropomyosin-related kinase B (TrkB) and extracellular signal-regulated kinases (ERK), components of BDNF signaling pathway. ANA-12, a selective TrkB antagonist, blocked the effects of EE on cognition, phosphorylation of TrkB and ERK, and neurogenesis. These results provide initial evidence that surgery reduces BDNF expression and neurogenesis in the hippocampus. Our results suggest that EE reduces surgery-induced impairment of learning, memory, and neurogenesis by preserving BDNF expression. © 2014, Springer Science+Business Media New York.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2015]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区神经科学

JCR分区：

出版当年[2014]版：

Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 4.6 最新[2023版] 4.7 最新五年平均 5.137 出版当年[2014版] 5.46 出版当年五年平均 5.286 出版前一年[2013版] 5.397 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA [2]Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, China

通讯作者：

通讯机构： [1]Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA

推荐引用方式(GB/T 7714)：

APA：

MLA：

Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression

文献详情

相关文献