机构：[1]Department of Interventional Neuroradiology,Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室医技科室放射科放射科首都医科大学附属天坛医院[2]Neuro-intensive Care Unit, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[3]China National Clinical Research Center for Neurological Diseases, Beijing, China[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[5]Department of Neurosurgery, Changzhou No. 1 People’s Hospital, Changzhou, China[6]Department of Neurology, Tangshan Gongren Hospital, Tangshan, China[7]Department of Neurology, Chongqing Sanxia Central Hospital, Chongqing, China[8]Department of Neurology, Daping Hospital, Chongqing, China[9]Department of Neurology, Baotou Central Hospital, Baotou, China[10]Department of Neurology, Hubei Zhongshan Hospital, Wuhan, China[11]Department of Neurology, Liaocheng 3rd People’s Hospital, Liaocheng, China[12]Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China[13]Department of Neurology, People’s Hospital of Linyi City, Linyi City, China[14]Department of Neurology, Tianjin Teda Hospital, Tianjin, China[15]Department of Neurology, Chifeng Municipal Hospital, Chifeng, China[16]Department of Neurology, Fuzhou PLA General Hospital, Fuzhou, China[17]Department of Neurology, Affiliated Hospital of Guiyang Medical College, Guiyang, China[18]Department of Neurology, QiLu Hospital of ShanDong University, Jinan, China[19]Department of Neurology, Yantai Hill Hospital, Yantai, China[20]Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, China[21]Department of Neurology, Xinan Hospital, Chongqing, China[22]Department of Neurology, Neurovascular Imaging Research Core, University of California, Los Angeles, Los Angeles, California, USA[23]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
OBJECTIVE: To estimate the association of different etiologies of cardioembolism (CE), intracranial arterial stenosis (ICAS), or the combination of these conditions with outcomes of mechanical thrombectomy in acute ischemic stroke. METHODS: Data from the intervention group of the Endovascular therapy for Acute ischemic Stroke Trial (EAST) were analyzed. In 140 patients, the presence of CE, ICAS, neither CE nor ICAS, or both conditions was assessed. The primary outcome was a favorable outcome at 90 days (modified Rankin Scale score 0-2); secondary outcomes included successful reperfusion (modified Thrombolysis In Cerebral Infarction grade 2b-3), symptomatic intracerebral hemorrhage, and 90-day mortality. RESULTS: Of 140 patients, 47 had neither CE nor ICAS, 35 had ICAS but not CE, 46 had CE but not ICAS, and 12 had both CE and ICAS. The rate of favorable outcome was 67.1% in the no CE and no ICAS group, 74.3% in the ICAS without CE group, 41.3% in the CE without ICAS group, and 33.3% in the CE and ICAS group. The CE and ICAS group had poor outcomes (odds ratio =0.20 after adjusting for age, sex, and National Institutes of Health Stroke Scale score; 95% confidence interval, 0.04-0.95; P = 0.043). No significant differences were observed in secondary outcomes. CONCLUSIONS: The presence of both CE and ICAS was associated with poor outcome in patients with anterior circulation large-vessel occlusion treated with endovascular thrombectomy. Future studies are warranted to further explore this association.
第一作者机构：[1]Department of Interventional Neuroradiology,Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Neuro-intensive Care Unit, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
通讯作者：
通讯机构：[1]Department of Interventional Neuroradiology,Beijing Tiantan Hospital, Capital Medical University, Beijing, China[3]China National Clinical Research Center for Neurological Diseases, Beijing, China[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Deng Yiming,Jia Baixue,Huo Xiaochuan,et al.Association of Cardioembolism and Intracranial Arterial Stenosis with Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke[J].WORLD NEUROSURGERY.2019,121:E146-E150.doi:10.1016/j.wneu.2018.09.058.
APA：
Deng, Yiming,Jia, Baixue,Huo, Xiaochuan,Peng, Ya,Cao, Yibin...&Miao, Zhongrong.(2019).Association of Cardioembolism and Intracranial Arterial Stenosis with Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke.WORLD NEUROSURGERY,121,
MLA：
Deng, Yiming,et al."Association of Cardioembolism and Intracranial Arterial Stenosis with Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke".WORLD NEUROSURGERY 121.(2019):E146-E150
