机构：[a]School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China[b]Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, Texas[c]Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan[d]the Children’s Hospital of Fudan University, National Center for Children’s Health, Shanghai, China
BACKGROUND Few studies have evaluated the health benefits of omega-3 fatty acid supplementation against fine particulate matter (aerodynamic diameter <2.5 mu m [PM2.5]) exposure in highly polluted areas. OBJECTIVES The authors sought to evaluate whether dietary fish-oil supplementation protects cardiovascular health against PM2.5 exposure in China. METHODS This is a randomized, double-blinded, and placebo-controlled trial among 65 healthy college students in Shanghai, China. Participants were randomly assigned to either the placebo group or the intervention group with dietary fish-oil supplementation of 2.5 g/day from September 2017 to January 2018, and received 4 rounds of health examinations in the last 2 months of treatments. Fixed-site PM2.5 concentrations on campus were measured in real time. The authors measured blood pressure and 18 biomarkers of systematic inflammation, coagulation, endothelial function, oxidative stress, antioxidant activity, cardiometabolism, and neuroendocrine stress response. Acute effects of PM2.5 on these outcomes were evaluated within each group using linear mixed-effect models. RESULTS The average PM2.5 level was 38 mu g/m(3) during the study period. Compared with the placebo group, the fish-oil group showed relatively stable levels of most biomarkers in response to changes in PM2.5 exposure. Between-group differences associated with PM2.5 exposure varied by biomarkers and by lags of exposure. The authors observed beneficial effects of fish-oil supplementation on 5 biomarkers of blood inflammation, coagulation, endothelial function, oxidative stress, and neuroendocrine stress response in the fish-oil group at a false discovery rate of <0.05. CONCLUSIONS This trial shows that omega-3 fatty acid supplementation is associated with short-term subclinical cardiovascular benefits against PM2.5 exposure among healthy young adults in China. (Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution; NCT03255187) (C) 2019 by the American College of Cardiology Foundation.
第一作者机构：[a]School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[a]School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China[d]the Children’s Hospital of Fudan University, National Center for Children’s Health, Shanghai, China[*1]Department of Environmental Health, School of Public Health, Fudan University, P.O. Box 249, 130 Dong-An Road, Shanghai 200032, China.
推荐引用方式(GB/T 7714)：
Zhijing Lin,Renjie Chen,Yixuan Jiang,et al.Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China[J].JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY.2019,73(16):2076-2085.doi:10.1016/j.jacc.2018.12.093.
APA：
Zhijing Lin,Renjie Chen,Yixuan Jiang,Yongjie Xia,Yue Niu...&Haidong Kan.(2019).Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,73,(16)
MLA：
Zhijing Lin,et al."Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 73..16(2019):2076-2085
医学