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Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population

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资源类型：

收录情况： ◇ SCIE

作者：
Wang, Ziqi[a,b,c,d] * ; Zhang, Jishui[e,f] * ; Lu, Tianlan[a,b,c,d] * ; Zhang, Tian[a,b,c,d] ; Jia, Meixiang[a,b,c,d] ; Ruan, Yanyan[a,b,c,d] ; Zhang, Dai[a,b,c,d,g,h,*1] ; Li, Jun[a,b,c,d,*1] ; Wang, Lifang[a,b,c,d,*1] ;
机构： [a]Peking University Sixth Hospital, Beijing 100191, China [b]Peking University Institute of Mental Health, Beijing 100191, China [c]NHC Key Laboratory of Mental Health (Peking University), Beijing 100191, China [d]National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China [e]Department of Mental Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China [f]National Center for Children's Health, Beijing 100045, China [g]Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China [h]PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
出处：
DOI： 10.1016/j.pnpbp.2018.12.016
ISSN：

关键词： Autism Family-based association study Genome-wide association study Replication Single-nucleotide polymorphism

摘要：
Autism is a complex neurodevelopmental disorder with high heritability. Previous genome-wide association studies (GWAS) demonstrated that some single-nucleotide polymorphisms (SNPs) were significantly associated with autism, while other studies focusing on these GWAS hits showed inconsistent results. Besides, the association between these variants and autism in the Chinese Han population remains unclear. Therefore, this family-based association study was performed in 640 Chinese Han autism trios to investigate the association between autism and 7 SNPs with genome-wide significance in previous GWAS (rs4307059 near MSNP1AS, rs4141463 in MACROD2, rs2535629 in ITIH3, rs11191454 in AS3MT, rs1625579 in MIR137HG, rs11191580 in NT5C2, and rs1409313 in CUEDC2). The results showed a nominal association between the T allele of rs4307059 and autism under both additive model (T > C, Z = 2.250, P = .024) and recessive model (T > C, Z = 2.109, P = .035). The findings provided evidence that rs4307059 near MSNP1AS might be a susceptibility variant for autism in the Chinese Han population.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471383, 81471360, 81501183, 81730037, 81871077]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学 2 区 药学 2 区 精神病学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学 2 区 药学 2 区 精神病学
JCR分区：
出版当年[2017]版：
Q1 PHARMACOLOGY & PHARMACY Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY Q2 NEUROSCIENCES
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Peking University Sixth Hospital, Beijing 100191, China [b]Peking University Institute of Mental Health, Beijing 100191, China [c]NHC Key Laboratory of Mental Health (Peking University), Beijing 100191, China [d]National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
共同第一作者：
通讯作者：
通讯机构： [a]Peking University Sixth Hospital, Beijing 100191, China [b]Peking University Institute of Mental Health, Beijing 100191, China [c]NHC Key Laboratory of Mental Health (Peking University), Beijing 100191, China [d]National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China [g]Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China [h]PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China [*1]Peking University Institute of Mental Health, 51, Hua Yuan Bei Road, Beijing 100191, China.
推荐引用方式(GB/T 7714)：
Wang Ziqi,Zhang Jishui,Lu Tianlan,et al.Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population[J].PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY.2019,92:194-198.doi:10.1016/j.pnpbp.2018.12.016.
APA：
Wang, Ziqi,Zhang, Jishui,Lu, Tianlan,Zhang, Tian,Jia, Meixiang...&Wang, Lifang.(2019).Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,92,
MLA：
Wang, Ziqi,et al."Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 92.(2019):194-198

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