Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the wide individual variations in fat distribution, degree of fatness or health risks, and genetic variants identified in the genome-wide association studies (GWAS). In this review, we will address this important issue with the introduction of phenome, phenomics, and phenome-wide association study (PheWAS). We will discuss the new paradigm shift from GWAS to PheWAS in obesity research. In the era of precision medicine, phenomics and PheWAS provide the required approaches to better definition and classification of obesity according to the association of obese phenome with their unique molecular makeup, lifestyle, and environmental impact.
基金：
NHLBI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01 HL113598]; NIMH NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [F31 MH106252]
Zhang Y. -P.,Zhang Y. -Y.,Duan D. D..From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research[J].PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE.2016,140:185-231.doi:10.1016/bs.pmbts.2016.02.003.
APA：
Zhang, Y. -P.,Zhang, Y. -Y.&Duan, D. D..(2016).From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research.PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE,140,
MLA：
Zhang, Y. -P.,et al."From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research".PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE 140.(2016):185-231
