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Current progress of genetic and epigenetic studies of cerebral palsy

ТЕКУЩИЙ ПРОГРЕСС ГЕНЕТИЧЕСКИХ И ЭПИГЕНЕТИЧЕСКИХ ИССЛЕДОВАНИЙ ДЕТСКОГО ЦЕРЕБРАЛЬНОГО ПАРАЛИЧА

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机构： [a]Nanfang Hospital, Southern Medical University, 1838 Guangzhou Da Dao Bei, Gunagzhou, 510515, China [b]Third Affiliated Hospital, Guangzhou Medical University, 63 Duobao Lu, Guangzhou, Guangdong, 510150, China [c]Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 56 Nan-Li-Shi Road, Beijing, 10045, China [d]New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY

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关键词： Cerebral palsy Epigenetics Etiology Genetics Mini-review

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Cerebral palsy (CP) is a heterogeneous condition, with cases sharing the common feature of non-progressive dysfunction of movement and posture. Although widely studied, the etiology of CP is not yet well understood. It is believed that most cases of CP arise from intrauterine injury to the developing brain. Increasing evidence suggests that (epi)genetic factors might collectively account for a large number of CP cases. In this mini-review, we focus mainly on the genetic and epigenetic aspects of recent progress in understanding the etiology of CP. © 2019 Bionika Media Ltd.. All rights reserved.

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第一作者机构： [a]Nanfang Hospital, Southern Medical University, 1838 Guangzhou Da Dao Bei, Gunagzhou, 510515, China [b]Third Affiliated Hospital, Guangzhou Medical University, 63 Duobao Lu, Guangzhou, Guangdong, 510150, China [c]Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 56 Nan-Li-Shi Road, Beijing, 10045, China [d]New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY

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