机构：[a]Department of Psychology, Queens College, The City University of New York, Queens, NY, USA[b]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[c]China National Clinical Research Center for Neurological Diseases, Beijing, China[d]School of Psychology, Capital Normal University, Beijing, China[e]Beijing Key Laboratory of Behavior and Mental Health, School of Psychological and Cognitive Sciences, Peking University, Beijing, China[f]Department of Psychology, Columbia University in the City of New York, USA[g]Institut du Cerveau et de la Moelle epiniere, ICM, INSERM U-1127, CNRS UMR 7225, Sorbonne Universite, Paris, France[h]Department of Computer Science, The Graduate Center, The City University of New York, New York, NY, USA[i]Department of Computer Science, Queens College, The City University of New York, Queens, NY, USA[j]Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA[k]Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA[l]Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Cognitive control, with a limited capacity, is a core process in human cognition for the coordination of thoughts and actions. Although the regions involved in cognitive control have been identified as the cognitive control network (CCN), it is still unclear whether a specific region of the CCN serves as a bottleneck limiting the capacity of cognitive control (CCC). Here, we used a perceptual decision-making task with conditions of high cognitive load to challenge the CCN and to assess the CCC in a functional magnetic resonance imaging study. We found that the activation of the right anterior insular cortex (AIC) of the CCN increased monotonically as a function of cognitive load, reached its plateau early, and showed a significant correlation to the CCC. In a subsequent study of patients with unilateral lesions of the AIC, we found that lesions of the AIC were associated with a significant impairment of the CCC. Simulated lesions of the AIC resulted in a reduction of the global efficiency of the CCN in a network analysis. These findings suggest that the AIC, as a critical hub in the CCN, is a bottleneck of cognitive control.
基金：
National Institute of Mental Health of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01 MH094305]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600931, 81328008, 81729001]; NSFNational Science Foundation (NSF) [IIS1718802]; Beijing Municipal Administration of Hospitals' Youth Program [QML20170503]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
最新[2023]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2017]版：
Q1NEUROSCIENCESQ1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1NEUROSCIENCESQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Department of Psychology, Queens College, The City University of New York, Queens, NY, USA
共同第一作者：
通讯作者：
通讯机构：[a]Department of Psychology, Queens College, The City University of New York, Queens, NY, USA[b]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[c]China National Clinical Research Center for Neurological Diseases, Beijing, China[e]Beijing Key Laboratory of Behavior and Mental Health, School of Psychological and Cognitive Sciences, Peking University, Beijing, China[k]Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA[*1]Department of Psychology, Queens College, The City University of New York, 65-30 Kissena Blvd., Queens, NY, 11367, USA.[*2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.6, TianTan XiLi, Dongcheng District, Beijing, 100050, China.[*3]School of Psychological and Cognitive Sciences, Peking University, Wusi Road, Haidian, Beijing, 100871, China.
推荐引用方式(GB/T 7714)：
Tingting Wu,Xingchao Wang,Qiong Wu,et al.Anterior insular cortex is a bottleneck of cognitive control[J].NEUROIMAGE.2019,195:490-504.doi:10.1016/j.neuroimage.2019.02.042.
APA：
Tingting Wu,Xingchao Wang,Qiong Wu,Alfredo Spagna,Jiaqi Yang...&Jin Fan.(2019).Anterior insular cortex is a bottleneck of cognitive control.NEUROIMAGE,195,
MLA：
Tingting Wu,et al."Anterior insular cortex is a bottleneck of cognitive control".NEUROIMAGE 195.(2019):490-504
医学