机构：[1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China医技科室职能科室临床流行病与循证医学中心医学影像中心首都医科大学附属北京儿童医院[2]Research Center for Brain-Inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China[3]University of Chinese Academy of Sciences, Beijing, China[4]Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia 19104, PA, USA[5]Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China医技科室职能科室临床流行病与循证医学中心血液中心首都医科大学附属北京儿童医院[6]Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, PA, USA
PurposePrevious studies have investigated the brain structural abnormalities in children with type I Gaucher disease (GD). The purpose of our study is to investigate the topological efficiency of the brain functional network in children with type 1 GD.MethodsTwenty-two children diagnosed with type 1 GD and 22 sex- and age-matched healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) examination. For longitudinal study, the GD patients underwent rs-fMRI examination again after 4.6years. Graph theoretical analysis was used to assess the brain network topological properties at the global and regional levels.ResultsCompared with the HCs, the children with type 1 GD showed a decreased efficiency in functional segregation with a decreased (normalized clustering coefficient). In addition, the balance between functional segregation and integration was disrupted with decreased small-worldness (sigma). At the regional level, the children with type 1 GD showed significantly decreased nodal degree and efficiency in the right precentral gyrus (PreCG.R) and left postcentral gyrus (PoCG.L). The significantly altered , sigma, and nodal degree in the PreCG.R and PoCG.L were negatively correlated with the disease duration. No significant alterations in the global and regional topological properties were identified in these patients over time.ConclusionCompared with that of the HCs, the efficiency of the brain functional network in the children with type 1 GD was disrupted, and regional involvement was located in motor- and sensory-related regions. The efficiency of the brain functional network in these patients remained stable over time.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81671651]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区核医学4 区临床神经病学4 区神经成像
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
JCR分区：
出版当年[2017]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3CLINICAL NEUROLOGYQ3NEUROIMAGING
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROIMAGING
第一作者机构：[1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
通讯作者：
通讯机构：[1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
推荐引用方式(GB/T 7714)：
Zhang Miao,Wang Shengpei,Hu Di,et al.Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study[J].NEURORADIOLOGY.2019,61(1):63-70.doi:10.1007/s00234-018-2104-3.
APA：
Zhang, Miao,Wang, Shengpei,Hu, Di,Kang, Huiying,Ouyang, Minhui...&Peng, Yun.(2019).Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study.NEURORADIOLOGY,61,(1)
MLA：
Zhang, Miao,et al."Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study".NEURORADIOLOGY 61..1(2019):63-70
