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Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro

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收录情况： ◇ SCIE

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机构： [1]Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

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关键词： Propranolol Cobalt chloride Human umbilical vein endothelial cells Hemangioma Hypoxia

摘要：

Background/Aims: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs). Methods: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Effects of propranolol on apoptosis and expressions of cell cycle-related genes, CDK4 and cyclin D1, were detected by flow cytometry and RT-PCR respectively. The release of vascular endothelial growth factor (VEGF) and lactate dehydrogenase (LDH) was measured by enzyme-linked immunosorbent assay. Results: Propranolol significantly inhibited the CoCl2-induced hypoxic proliferation of HUVECs in a dose-dependent manner, and also induced apoptosis and suppressed the expression of CDK4 and cyclin D1. Propranolol also decreased the release of VEGF and LDH in the supernatant. Conclusions: Propranolol could inhibit CoCl2-induced hypoxic proliferation of HUVECs through inducing apoptosis and cell cycle arrest. (C) 2018 S. Karger AG, Basel

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区药学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区药学

JCR分区：

出版当年[2017]版：

Q4 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q2 PHARMACOLOGY & PHARMACY

影响因子： 2.9 最新[2023版] 2.5 最新五年平均 1.538 出版当年[2017版] 1.62 出版当年五年平均 1.442 出版前一年[2016版] 1.615 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

通讯作者：

通讯机构： [1]Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [*1]Department of Dermatology, Beijing Children’s Hospital Capital Medical University, National Center for Children’s Health No. 56 South Lishi Road, Beijing 100045 (China)

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