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Ligustrazine Protects Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells by Modulating Mitochondrial Dysfunction

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收录情况： ◇ SCIE

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机构： [1]Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China [2]Center for Pediatric Cardiac Surgery, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

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关键词： Cell apoptosis Homocysteine Human umbilical vein endothelial cells (HUVECs) Ligustrazine Mitochondria dysfunction

摘要：

Ligustrazine is one of the alkaloid compounds isolated from the traditional Chinese herb, which shows protective effects on cardiovascular disorders. High homocysteine (Hcy) level can predict cardiovascular-related events including death. In this study, we used Hcy to stimulate the human umbilical vein endothelial cells (HUVECs) and investigated the protective effect of ligustrazine on endothelial dysfunction by assessing the cell apoptosis, oxidative damage, mitochondrial dysfunction, and the potential molecular pathways. Our results clearly showed that ligustrazine increased HUVEC cell viability, decreased the dehydrogenase (LDH) level, and inhibited HUVEC apoptosis, which was associated with the attenuation of attenuated oxidative damage. The mitochondrial-dependent pathway was closely related in the regulation of ligustrazine, reflected by the attenuated mitochondrial membrane potential change and decreased cytochrome c release from the mitochondria to the cytosol. Ligustrazine may protect Hcy-induced apoptosis in HUVECs by attenuating oxidative damage and modulating mitochondrial dysfunction. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 4 区心脏和心血管系统

最新[2023]版：

大类 | 3 区医学

小类 | 4 区心脏和心血管系统 4 区医学：研究与实验

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出版当年[2017]版：

Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Q3 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.4 最新[2023版] 2.9 最新五年平均 2.337 出版当年[2017版] 2.577 出版当年五年平均 2.319 出版前一年[2016版] 2.756 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China

通讯作者：

通讯机构： [1]Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China

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