详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

m(6)A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China [2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China [3]China National Clinical Research Center for Neurological Diseases, Beijing, China [4]Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China [5]Chinese Glioma Genome Atlas Network (CGGA) [6]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, China

出处：

DOI：

ISSN：

关键词： RNA modification methyltransferase demethylases epigenetics prognostic signature

摘要：

N6-methyladenosine (m(6)A) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the m(6)A RNA methylation regulators ("writers", "erasers" and "readers"). Here, we demonstrate that most of the thirteen main m(6)A RNA methylation regulators are differentially expressed among gliomas stratified by different clinicopathological features in 904 gliomas. We identified two subgroups of gliomas (RM1/2) by applying consensus clustering to m(6)A RNA methylation regulators. Compared with the RM1 subgroup, the RM2 subgroup correlates with a poorer prognosis, higher WHO grade, and lower frequency of IDH mutation. Moreover, the hallmarks of epithelial-mesenchymal transition and TNF alpha signaling via NF-kappa B are also significantly enriched in the RM2 subgroup. This finding indicates that m(6)A RNA methylation regulators are closely associated with glioma malignancy. Based on this finding, we derived a risk signature, using seven m(6)A RNA methylation regulators, that is not only an independent prognostic marker but can also predict the clinicopathological features of gliomas. Moreover, m(6)A regulators are associated with the mesenchymal subtype and TMZ sensitivity in GBM. In conclusion, m(6)A RNA methylation regulators are crucial participants in the malignant progression of gliomas and are potentially useful for prognostic stratification and treatment strategy development.

基金：

语种：

高被引：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区老年医学 3 区细胞生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区老年医学

JCR分区：

出版当年[2017]版：

Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 5.179 出版当年[2017版] 5.437 出版当年五年平均 4.867 出版前一年[2016版] 5.515 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China [3]China National Clinical Research Center for Neurological Diseases, Beijing, China [5]Chinese Glioma Genome Atlas Network (CGGA)

共同第一作者：

通讯作者：

通讯机构： [1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China [2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China [3]China National Clinical Research Center for Neurological Diseases, Beijing, China [4]Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China [5]Chinese Glioma Genome Atlas Network (CGGA) [6]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

m(6)A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

相关文献

m(6)A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas