机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[3]China National Clinical Research Center for Neurological Diseases, Beijing, China[4]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China
Objective To investigate the relationship between tumor characteristics and the preoperative counts of immune cells in peripheral blood test in glioma patients. Methods We included 260 WHO grades II-IV patients who had preoperative peripheral blood test result from Sanbo hospital as training set. The 66 patients from Tiantan hospital was obtained for validation. RNA sequencing data from CGGA and TCGA datasets were used to evaluate the features of neutrophil subtype and lymphocyte subtype in glioma. Results We revealed that the count of preoperative lymphocytes, eosinophils and neutrophils were associated with glioma grades. Neutrophil-to-lymphocyte ratio (NLR) <3.2 was associated with better prognosis, whereas increased NLR was strongly corresponding with a poor prognosis. Lymphocyte type glioma patients demonstrated a positive correlation with isocitrate dehydrogenase (IDH) mutation and lower grade. IDH mutant glioma contained a higher proportion of tumor-infiltrating lymphocytes than IDH wild-type glioma. The immune subtype (neutrophil subtype and lymphocyte subtype) was an independent prognostic factor in glioma. Conclusion Our data demonstrated that NLR was an important prognostic factor in glioma. We classified that the immune subtype of glioma may contribute to a better understanding of disease pathogenesis and lead to the identification of new therapeutic targets for glioma patients.
基金：
National Key Research and Development Plan [2016YFC0902500]; Beijing Science and Technology Plan [Z141100000214009]; Capital Medical Development Research Fund [2016-1-1072]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81802483]
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[3]China National Clinical Research Center for Neurological Diseases, Beijing, China[4]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China[*1]Department of Neurosurgery, Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.[*2]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Wang Zhi-Liang,Zhang Chuan-Bao,Liu Yu-Qing,et al.Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction[J].CNS NEUROSCIENCE & THERAPEUTICS.2019,25(8):876-883.doi:10.1111/cns.13120.
APA：
Wang, Zhi-Liang,Zhang, Chuan-Bao,Liu, Yu-Qing,Wang, Zheng&Jiang, Tao.(2019).Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction.CNS NEUROSCIENCE & THERAPEUTICS,25,(8)
MLA：
Wang, Zhi-Liang,et al."Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction".CNS NEUROSCIENCE & THERAPEUTICS 25..8(2019):876-883
