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Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma

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收录情况： ◇ SCIE ◇ CSCD-C

作者：

机构： [1]Otolaryngology, Children’s Hospital of Hebei Province, Shijiazhuang 050031, China [2]Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China [3]Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China [4]Department of Surgical Oncology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China

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关键词： clinic-pathological characteristics pediatric papillary thyroid cancer TERT C228T mutation

摘要：

The aims of the present study were to reveal the prevalence of the TERT C228T mutation in pediatric papillary thyroid carcinoma (PPTC) and to further investigate the role of the TERT C228T mutation in PPTC. We also tested another TERT mutation, TERT C250T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC (41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228T mutation analysis was performed. Chi-squared analysis, Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228T mutation presented in 13 (27.1%) of the 48 PPTC patients and 10 (24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228T mutation and those without in terms of modified radical neck dissection, multifocality, capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer (AJCC) tumor stage (P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage (P=0.009) and American Thyroid Association (ATA) PPTC stage (P=0.021) between patients with and without the TERT C228T mutation. These findings indicate that the TERT C228T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC. © 2019, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 3 区生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区生物学

JCR分区：

出版当年[2017]版：

Q1 BIOLOGY

最新[2023]版：

Q1 BIOLOGY

影响因子： 8 最新[2023版] 7.3 最新五年平均 3.085 出版当年[2017版] 2.328 出版当年五年平均 2.781 出版前一年[2016版] 3.583 出版后一年[2018版]

第一作者：

第一作者机构： [1]Otolaryngology, Children’s Hospital of Hebei Province, Shijiazhuang 050031, China [2]Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China

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通讯作者：

通讯机构： [1]Otolaryngology, Children’s Hospital of Hebei Province, Shijiazhuang 050031, China [2]Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China [3]Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China

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Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma

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