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Comparative transcriptome analysis reveals involvement of TLR-2 signaling in the pathogenesis of intracranial aneurysm

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, 6 Tiantan Xili, 100050 Beijing, China

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关键词： Intracranial aneurysms TLR-2 Gene expression profiles

摘要：

In this study, we collected and analyzed 15 aneurysmal and 17 superficial temporal artery (STA) specimens from 32 Chinese patients with intracranial aneurysm. Total RNA was extracted and reverse transcribed to cDNA, and genome-wide expression profiling was performed by using the Affymetrix Human Genome U133 Plus 2.0 Array which allows a total number of 38,500 genes to be analyzed at the same time. Real-time RT-PCR was performed to verify the expression level of 8 selected genes. We found significant up-regulation of the TLR-2 gene. This result suggests that TLR-2 plays a key role in the formation of intracranial aneurysm in a Chinese population. To our knowledge, this study is the first to use the Human Genome U133 Plus 2.0 Array to analyze the gene expression profiles in Chinese patients with intracranial aneurysm. (C) 2017 Published by Elsevier Ltd.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

JCR分区：

出版当年[2016]版：

Q4 NEUROSCIENCES Q4 CLINICAL NEUROLOGY

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.9 最新[2023版] 1.9 最新五年平均 1.557 出版当年[2016版] 1.545 出版当年五年平均 1.387 出版前一年[2015版] 1.64 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, 6 Tiantan Xili, 100050 Beijing, China

通讯作者：

通讯机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, 6 Tiantan Xili, 100050 Beijing, China

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