机构：[a]San Francisco Veteran’s Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA[b]Departments of Neurological Surgery, University of California San Francisco, San Francisco, CA 94158, USA[c]Department of Neurological Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[d]Department of Neurological Surgery, Second Affiliated Hospital of Zhejiang University Medical College, Hangzhou, China[e]Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA 94121, USA
Unilateral brain injury is known to disrupt the balance between the two cortices, as evidenced by an abnormally high interhemispheric inhibitory drive from motor cortex M1(intact) to M1(lesioned) transmitted transcallosally. Our previous work has shown that the deletion of homeobox gene Emx1a not only led to the agenesis of the corpus callosum (cc), but also to reduced hippocampal neurogenesis. The current study sought to determine whether lacking the cc affected the recovery of forelimb function and hippocampal plasticity following training of the affected limb in mice with unilateral traumatic brain injuries (TBI). One week after TBI, produced by a controlled cortical impact to impair the preferred limb, Emx1 wild type (WT) and knock out (I(0) mice were subjected to the single-pellet reaching task with the affected limb for 4 weeks. Both TBI and Emx1 deletion had overall adverse effects on the successful rate of reaching. However, TBI significantly affected reaching performance only in the WT mice and not in the 1(0 mice. Both TBI and Emx1 gene deletion also negatively affected hippocampal neurogenesis, demonstrated by a reduction in doublecortin (DCX)-expressing immature neurons, while limb training enhanced DCX expression. However, limb training increased DCX cells in KO mice only in the TBI-treated group, whereas it induced neurogenesis in both WT mice groups regardless of the treatment. Our finding also suggests that limb training enhances neuroplasticity after brain injury at functionally remote regions including the hippocampus, which may have implications for promoting overall recovery of function after TBI. Published by Elsevier B.V.
基金：
National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 NS071050]; Department of Veteran AffairsUS Department of Veteran Affairs [I01RX000655]; Department of DefenseUnited States Department of Defense [W81XWH-05-1]
第一作者机构：[a]San Francisco Veteran’s Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA[b]Departments of Neurological Surgery, University of California San Francisco, San Francisco, CA 94158, USA
共同第一作者：
通讯作者：
通讯机构：[a]San Francisco Veteran’s Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA[b]Departments of Neurological Surgery, University of California San Francisco, San Francisco, CA 94158, USA[*1]Department of Neurological Surgery (112C), Universityof California at San Francisco and Department of Veterans Affairs Medical Center,1700 Owens Street, San Francisco, California 94158, USA.
推荐引用方式(GB/T 7714)：
Melanie Neumann,Wei Liu,Chongran Sun,et al.Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum[J].BEHAVIOURAL BRAIN RESEARCH.2018,340:165-171.doi:10.1016/j.bbr.2016.09.013.
APA：
Melanie Neumann,Wei Liu,Chongran Sun,Shih Yen Yang,Linda J. Noble-Haeusslein&Jialing Liu.(2018).Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum.BEHAVIOURAL BRAIN RESEARCH,340,
MLA：
Melanie Neumann,et al."Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum".BEHAVIOURAL BRAIN RESEARCH 340.(2018):165-171
