The rs696880 Polymorphism in the Nogo-A Receptor Gene (RTN4R) Is Associated With Susceptibility to Sporadic Amyotrophic Lateral Sclerosis in the Chinese Population
机构：[1]Department of Neurology, Peking University Third Hospital, Beijing, China,[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[3]Key Laboratory for Neuroscience, Ministry of Education/National Health & Family Planning Commission, Peking University, Beijing, China
Single-nucleotide polymorphisms (SNPs) in the Nogo-A receptor gene (RTN4R) have been associated with increased risk for sporadic amyotrophic lateral sclerosis (SALS) in the French population. In the present study, we investigated the associations between RTN4R tag SNPs and SALS in a large Chinese population. Four tag SNPs (rs854971, rs887765, rs696880 and rs1567871) in the RTN4R gene with an r(2) threshold of 0.8 and a minor allele frequency (MAF) greater than 0.2% were selected based on Chinese population data from HapMap. A total of 499 SALS patients and 503 healthy controls were genotyped for the SNPs by SNaPshot technology. Haplotype analysis of the four SNPs was performed using the SHEsis software platform. The results showed a significant association between the rs696880 risk allele (A) and SALS in the Han Chinese population (P = 0.009, odds ratio (OR) = 1.266 [1.06-1.51]). The allele and genotype frequencies of rs854971, rs887765 and rs1567871 were not associated with SALS. The distribution of the GAAT haplotype was different between the case and control groups (P = 0.008, OR = 1.289 [1.066-1.558]). In conclusion, our study showed an association between the RTN4R SNP rs696880 and the risk of SALS in the Han Chinese population, with the A allele increasing risk.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81030019]
第一作者机构：[1]Department of Neurology, Peking University Third Hospital, Beijing, China,[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Department of Neurology, Peking University Third Hospital, Beijing, China,[3]Key Laboratory for Neuroscience, Ministry of Education/National Health & Family Planning Commission, Peking University, Beijing, China
推荐引用方式(GB/T 7714)：
Xu Lianping,Li Jiao,Tian Danyang,et al.The rs696880 Polymorphism in the Nogo-A Receptor Gene (RTN4R) Is Associated With Susceptibility to Sporadic Amyotrophic Lateral Sclerosis in the Chinese Population[J].FRONTIERS IN AGING NEUROSCIENCE.2018,10(APR):-.doi:10.3389/fnagi.2018.00108.
APA：
Xu, Lianping,Li, Jiao,Tian, Danyang,Chen, Lu,Tang, Lu&Fan, Dongsheng.(2018).The rs696880 Polymorphism in the Nogo-A Receptor Gene (RTN4R) Is Associated With Susceptibility to Sporadic Amyotrophic Lateral Sclerosis in the Chinese Population.FRONTIERS IN AGING NEUROSCIENCE,10,(APR)
MLA：
Xu, Lianping,et al."The rs696880 Polymorphism in the Nogo-A Receptor Gene (RTN4R) Is Associated With Susceptibility to Sporadic Amyotrophic Lateral Sclerosis in the Chinese Population".FRONTIERS IN AGING NEUROSCIENCE 10..APR(2018):-
