机构：[1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, National Center for Children’s Health, China医技科室职能科室临床流行病与循证医学中心医学影像中心首都医科大学附属北京儿童医院[2]Department of Radiology, Children’s Hospital of Philadelphia, PA, United States[3]Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China,科研平台职能科室出生缺陷遗传学研究室临床流行病与循证医学中心儿科研究所首都医科大学附属北京儿童医院[4]MOE Key Laboratory of Major Diseases in Children, China[5]Beijing Key Laboratory for Genetics of Birth Defects, China[6]Peking University, School of Psychological and Cognitive Sciences, Beijing, China[7]Peking University, Peking-Tsinghua Center for Life Sciences, Beijing, China[8]Hematology Oncology Center Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China医技科室职能科室临床流行病与循证医学中心血液中心首都医科大学附属北京儿童医院[9]Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States[10]Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, United States
Objectives: To investigate white matter (WM) microstructural alterations in type I Gaucher disease (type I GD) pediatric patients and explore the correlation between the disease duration and WM changes. Methods: Twenty-two GD patients and twenty-two sex-and age-matched typical development (TD) children were recruited. Changes in WM were investigated using diffusion tensor imaging (DTI) and applying atlas-based tract analysis. For all DTI measurements, independent-samples t-test was applied to report significant differences between type I GD and TD. Partial correlation was applied to determine whether the disease duration was correlated with DTI measurements. Results: Bidirectional fractional anisotropy (FA) changes were found in the bilateral superior cerebellar peduncle, right posterior limb of the internal capsule, right posterior corona radiata, and right posterior thalamic radiation (p < 0.05). Higher mean diffusivity (MD) was found in the right superior corona radiata, middle cerebellar peduncle, right posterior thalamic radiation and right superior longitudinal fasciculus (p < 0.05) in type I GD. And higher radial diffusivity (RD) was also found in the left superior cerebellar peduncle (p < 0.05) in type I GD. The disease duration of type I GD patients is positively correlated with axial diffusivity and MD in multiple major WM tracts. Conclusion: DTI findings supported the microstructural alterations of multiple WM tracts in type I GD patients.
第一作者机构：[1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, National Center for Children’s Health, China[2]Department of Radiology, Children’s Hospital of Philadelphia, PA, United States
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, National Center for Children’s Health, China[*1]Department of Radiology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, No. 56 Nanlishi Road, West District, Beijing, 100045, China.
推荐引用方式(GB/T 7714)：
Kang Huiying,Zhang Miao,Ouyang Minhui,et al.Brain white matter microstructural alterations in children of type I Gaucher disease characterized with diffusion tensor MR imaging[J].EUROPEAN JOURNAL OF RADIOLOGY.2018,102:22-29.doi:10.1016/j.ejrad.2018.02.014.
APA：
Kang, Huiying,Zhang, Miao,Ouyang, Minhui,Guo, Ruolan,Yu, Qinlin...&Peng, Yun.(2018).Brain white matter microstructural alterations in children of type I Gaucher disease characterized with diffusion tensor MR imaging.EUROPEAN JOURNAL OF RADIOLOGY,102,
MLA：
Kang, Huiying,et al."Brain white matter microstructural alterations in children of type I Gaucher disease characterized with diffusion tensor MR imaging".EUROPEAN JOURNAL OF RADIOLOGY 102.(2018):22-29
