机构：[1]Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China医技科室职能科室临床流行病与循证医学中心血液中心首都医科大学附属北京儿童医院
Background: The pro-inflammatory cytokine, interleukin-6 (IL-6), stimulates the metastasis of several neoplasms. An association of its serum level and the single nucleotide polymorphism (SNP) rs1800795 with neuroblastoma (NB) has been reported in American and Italian cohorts. This study was to clarify whether the same association exists in Chinese children. Methods: A total of 130 NB patients. with 77 boys (59%), 53 girls (41%), mean age 41. 5 months, were assigned to two groups: high risk (II R) versus intermediate-low risk (non-HR), and 50 healthy children were randomly selected as the age-and gender-matched controls. Peripheral blood samples were analyzed to determine semm IL-6 level using enzyme linked immunosorbent assay and. rs1800795 SNPs phenotype using polymerase chain reaction and gene sequencing. Results: There were 87 NB patients in the HR group and 43 NB patients in the non-HR group. A comparison of allele and. genotype frequencies of the rs1800795 polymorphism between patients and controls found no association with NB risk > 0.05). The frequency of GG-GC genotype was higher in HR-NB patients than in non-HR-NB patients (64.4% vs. 48.8%, P = 0.02), and serum IL-6 level was much higher in 11R-NB patients with GG1GC genotype than in IIR-NB patients with CC genotype (4.36 1 1.1 pg/ml. vs. 1.83 +/- 1 0.5 pg/m1; P = 0.02), but not in Non-HR-NB patients. Conclusions: The polymorphism rs1800795 is associated with serum LL-6 level and level of NB risk. GCT genotype might indicate that the tumor is highly malignant (prone to metastasis) and associated with poor prognosis.
基金：
Beijing Municipal Commission of Science and Technology Capital Clinical Medicine Applied Research and Popularization Special Funding [Z151100004015159]
第一作者机构：[1]Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
通讯作者：
通讯机构：[1]Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China[*1]Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, , Beijing 100045, China
推荐引用方式(GB/T 7714)：
Zhao Qian,Jin Mei,Zhang Da-Wei,et al.Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children[J].CHINESE MEDICAL JOURNAL.2018,131(9):1075-1078.doi:10.4103/0366-6999.230719.
APA：
Zhao, Qian,Jin, Mei,Zhang, Da-Wei,Zhao, Wen,Wang, Xi-Si...&Ma, Xiao-Li.(2018).Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children.CHINESE MEDICAL JOURNAL,131,(9)
MLA：
Zhao, Qian,et al."Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children".CHINESE MEDICAL JOURNAL 131..9(2018):1075-1078
