机构：[1]Brain Tumor Research Center, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Laboratory of Biomedical Materials, Beijing 100050, PR China研究所北京市神经外科研究所首都医科大学附属天坛医院
Hypoxia is common in Glioblastoma (GBM). By regulating the 'hypoxia signaling cascade', hypoxia affects several processes including cell proliferation, invasion, and angiogenesis. Some studies have revealed that signal transducer and activator of transcription (STAT), including STAT1, is abnormal under hypoxia in several cancers. Here, we investigated the role of STAT1 under hypoxia in glioma progression. We found that STAT1 was downregulated under a hypoxic condition in U251 and U373. STAT1 overexpression can not only decrease proliferation, migration and invasion in U251 and U373 but also inhibit tube formation of HBMECs. Moreover, overexpression of STAT1 decreased tumor growth and prolonged the overall survival of xenograft mice. We also showed that STAT1 overexpression inhibited the expression of HIF-1 alpha and VEGF-A. Our work suggests that STAT1 plays a pivotal role as a tumor suppressor in glioma under hypoxia, and it could be a potential new therapeutic target in glioma.
基金：
National Natural Science FoundationNational Natural Science Foundation of China [81372354, 81302186]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7151002]; Beijing Health System High-level Personnel Building Foundation [2013-3-018]; Beijing Laboratory of Biomedical Materials Foundation [PXM2014_014226_000005]; Beijing Municipal Administration of Hospitals' Youth Program [QML20150505]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区药学4 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2016]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Brain Tumor Research Center, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Laboratory of Biomedical Materials, Beijing 100050, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Brain Tumor Research Center, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Laboratory of Biomedical Materials, Beijing 100050, PR China[*1]Brain Tumor Research Center, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing 100050, PR China
推荐引用方式(GB/T 7714)：
Yunsheng Zhang,Guishan Jin,Junwen Zhang,et al.Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGF-A in human glioma cells[J].BIOMEDICINE & PHARMACOTHERAPY.2018,104:566-575.doi:10.1016/j.biopha.2018.05.079.
APA：
Yunsheng Zhang,Guishan Jin,Junwen Zhang,Ruifang Mi,Yiqiang Zhou...&Fusheng Liu.(2018).Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGF-A in human glioma cells.BIOMEDICINE & PHARMACOTHERAPY,104,
MLA：
Yunsheng Zhang,et al."Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGF-A in human glioma cells".BIOMEDICINE & PHARMACOTHERAPY 104.(2018):566-575
