机构：[1]Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Changsha, China[2]Department of Neurosurgery, Beijing Tian Tan Hospital, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院
Background: Intracranial aneurysm (IA) rupture is life-threatening. However, the mechanisms underlying IA initiation, progression, and rupture remain poorly understood. In the present study, we examined the role of primary cilia in IA development. Results: IA was experimentally induced in mice with elastase and angiotensin II treatment. The number of cells with primary cilia was determined in both IA and peri-IA regions. The role of primary cilia in IA development was assessed through knocking out or manipulating the expression of important components of primary cilia. Finally the role of primary cilia in human IA patients was studied. In the mice model of IA, the primary cilia number was significantly decreased in the IA region. Knocking out Polycystin 1, Polycystin 2, and Intraflagellar Transport 88 in mice would increase the susceptibility of mice to IA development. The IA development could be modulated through manipulating the pathways that regulate primary cilia dynamics. And chemical screening showed that the three factors (PHA 680623, Rapamycin, and Forskolin) could efficiently suppress the IA development. Finally, we demonstrated that the primary cilia deficiency in IA development is conserved in humans. And IA patients had a higher frequency of gene mutations which are related to primary cilia regulation. Conclusion: Our study provides an important support for the role of primary cilia in the development of IA. The primary cilia stabilizing chemicals might be useful for preventing IA development.
基金：
National Natural Science Fund from the National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81370567]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|2 区外科3 区危重病医学3 区血液学3 区外周血管病
最新[2023]版：
大类|3 区医学
小类|3 区血液学3 区外周血管病3 区外科4 区危重病医学
JCR分区：
出版当年[2016]版：
Q1SURGERYQ2CRITICAL CARE MEDICINEQ2PERIPHERAL VASCULAR DISEASEQ2HEMATOLOGY
最新[2023]版：
Q1SURGERYQ2CRITICAL CARE MEDICINEQ2HEMATOLOGYQ2PERIPHERAL VASCULAR DISEASE
第一作者机构：[1]Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Changsha, China
通讯作者：
通讯机构：[1]Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Changsha, China[*1]Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Renmin Road, Changsha City, Hunan Province 410000, P.R. China
推荐引用方式(GB/T 7714)：
Min Liu,Jizong Zhao,Qian Zhou,et al.PRIMARY CILIA DEFICIENCY INDUCES INTRACRANIAL ANEURYSM[J].SHOCK.2018,49(5):604-611.doi:10.1097/SHK.0000000000000961.
