机构：[1]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室医技科室放射科放射科首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, China,[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[4]Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China,[5]Departments of Neuropsychiatry and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,首都医科大学附属天坛医院[6]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室医技科室放射科放射科首都医科大学附属天坛医院[7]School of Life Science, Beijing Institute of Technology, Beijing, China,[8]Key Laboratory of Convergence Medical Engineering System and Healthcare Technology, The Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing, China
Objective: This study aimed to investigate the association between cognitive impairment and cerebral haemodynamic changes in patients with chronic vertebra-basilar (VB) stenosis. Methods: Patients with severe posterior circulation VB stenosis and infarction or a history of infarction for more than 2 weeks from January 2014 to January 2015 were enrolled (n = 96). They were divided into three groups, namely, the computed tomography perfusion (CTP) normal group, the CTP compensated group, and the CTP decompensated group. Cognitive function was assessed using a validated Chinese version of the Mini-Mental State Examination (MMSE), the Frontal Assessment Battery (FAB), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Regression models were used to identify independent risk factors for cognitive impairment. Results: The MMSE and FAB scores of patients in the CTP decompensated group were significantly lower than those of patients in the CTP normal and CTP compensated groups (all p < 0.05). The RBANS total and its domain scores, including immediate memory, visual acuity, and delayed memory, in the CTP compensated and CTP decompensated groups were significantly lower than those in the CTP normal group (all p < 0.05). Multiple regression analyses showed that CTP compensation, CTP decompensation, severe VB tandem stenosis, and multiple infarctions were independent risk factors for cognitive impairment. Conclusions: Low perfusion caused by severe VB stenosis can lead to extensive cognitive impairments in areas such as immediate memory, visual span, and delayed memory.
基金：
National Key Research and Development Program of China [2018YFC0115400]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471752]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z161100001116122]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [Z171100001117057]
第一作者机构：[1]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]China National Clinical Research Center for Neurological Diseases, Beijing, China,[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]China National Clinical Research Center for Neurological Diseases, Beijing, China,[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[7]School of Life Science, Beijing Institute of Technology, Beijing, China,[8]Key Laboratory of Convergence Medical Engineering System and Healthcare Technology, The Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing, China
推荐引用方式(GB/T 7714)：
Deng Yiming,Wang Luyao,Sun Xuan,et al.Association Between Cerebral Hypoperfusion and Cognitive Impairment in Patients With Chronic Vertebra-Basilar Stenosis[J].FRONTIERS IN PSYCHIATRY.2018,9:-.doi:10.3389/fpsyt.2018.00455.
APA：
Deng, Yiming,Wang, Luyao,Sun, Xuan,Liu, Lian,Zhu, Meifang...&Gao, Feng.(2018).Association Between Cerebral Hypoperfusion and Cognitive Impairment in Patients With Chronic Vertebra-Basilar Stenosis.FRONTIERS IN PSYCHIATRY,9,
MLA：
Deng, Yiming,et al."Association Between Cerebral Hypoperfusion and Cognitive Impairment in Patients With Chronic Vertebra-Basilar Stenosis".FRONTIERS IN PSYCHIATRY 9.(2018):-
