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Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats

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收录情况： ◇ SCIE

作者：
Zhao Fangfang[1,2] * ; Zhong Liyuan[1,2] * ; Wang Yilin[1,2] ; Wang Rongliang[1,2] ; Yang Zhenhong[1,2] ; Luo Yumin[1,2,3] ; Zheng Yangmin[1,2] ;
机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China [3]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.intimp.2023.110271
ISSN：

关键词： Chronic cerebral hypoperfusion Dl-3-n-butylphthalide LC-MS/MS Untargeted metabolomics Cognitive impairment

摘要：
Chronic cerebral hypoperfusion (CCH) can cause cognitive impairments. Dl-3-n-butylphthalide (NBP) is widely used in neurological disorders; but, the role of NBP in CCH remains unclear. This study aimed to investigate the potential mechanism of NBP on CCH through untargeted metabolomics. Animals were divided into CCH, Sham, and NBP groups. A rat model of bilateral carotid artery ligation was used to simulate CCH. Cognitive function of the rats was assessed using the Morris water maze test. Additionally, we used LC-MS/MS to detect ionic intensities of metabolites between the three groups for off-target metabolism analysis and to screen for differential metabolites. The analysis showed an improvement in cognitive function in rats after NBP treatment. Moreover, metabolomic studies showed that the serum metabolic profiles of the Sham and CCH groups were significantly altered, and 33 metabolites were identified as potential biomarkers associated with the effects of NBP. These metabolites were enriched in 24 metabolic pathways.And the pathway of differential metabolite enrichment was further verified by immunofluorescence. Thus, the study provides a theoretical basis for the pathogenesis of CCH and the treatment of CCH by NBP, and supports a wider application of NBP drugs.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

基金：
Capital Funds for Health Improvement and Research (2020–2-1032), the National Natural Science Foundation of China (NSFC, Grant/Award Number: 81971222, and the Xuanwu Hospital Science Program for Fostering Young Scholars (QNPY2020005).
语种：
外文
被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
JCR分区：
出版当年[2021]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China [3]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Zhao Fangfang,Zhong Liyuan,Wang Yilin,et al.Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2023,119:doi:10.1016/j.intimp.2023.110271.
APA：
Zhao Fangfang,Zhong Liyuan,Wang Yilin,Wang Rongliang,Yang Zhenhong...&Zheng Yangmin.(2023).Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats.INTERNATIONAL IMMUNOPHARMACOLOGY,119,
MLA：
Zhao Fangfang,et al."Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats".INTERNATIONAL IMMUNOPHARMACOLOGY 119.(2023)

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