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LC-MS/MS metabolomic profiling of the protective butylphthalide effect in cerebral ischemia/reperfusion mice

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收录情况： ◇ SCIE

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机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China.

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关键词： Butylphthalide Cerebral ischemia/reperfusion Metabolomics LC-MS/MS Neuroprotective

摘要：

This study was designed to investigate metabolic biomarker changes and related metabolic pathways of Butylphthalide (NBP) on cerebral ischemia/reperfusion.In this study, a mouse cerebral ischemia/reperfusion (I/R) model was prepared using the middle cerebral artery occlusion method, and neurobehavioral score and 2, 3, 5-triphenyltetrazolium chloride (TTC) staining experiments were used to confirm the obvious NBP anti-cerebral ischemia effect. The protective effect of NBP in the mouse cerebral I/R model and its metabolic pathway and mechanism were investigated using mouse blood samples.The metabolic profiles of mice in the I/R+NBP, I/R, and sham groups were significantly different. Under the condition that I/R vs. sham was downregulated and I/R + NBP vs. I/R was upregulated, 88 differential metabolites, including estradiol, ubiquinone-2, 2-oxoarginine, and L-histidine trimethylbetaine, were screened and identified. The related metabolic pathways involved arginine and proline metabolism, oxidative phosphorylation, ubiquitin and other terpenoid-quinone biosynthesis, and estrogen signaling.Metabolomics was used to elucidate the NBP mechanism in cerebral ischemia treatment in mice, revealing synergistic NBP pharmacological characteristics with multiple targets.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区外周血管病 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学 4 区外周血管病

JCR分区：

出版当年[2021]版：

Q3 PERIPHERAL VASCULAR DISEASE Q4 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES Q3 PERIPHERAL VASCULAR DISEASE

影响因子： 2 最新[2023版] 2.1 最新五年平均 2.677 出版当年[2021版] 2.505 出版当年五年平均 2.136 出版前一年[2020版] 2.5 出版后一年[2022版]

第一作者：

第一作者机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China.

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通讯作者：

通讯机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China. [*1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

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