Aim: Follow-up investigations are often required for clenbuterol-positive cases. A method to distinguish doping abuse from meat contamination was developed. Materials & methods: A total of 26 volunteers were recruited to ingest clenbuterol contaminated-pork and clenbuterol tablets. Results: For 20 volunteers, after ingestion of contaminated-pork, R-(-)/S-(+)-clenbuterol ratio was <1.0, while the value was >1.0 after taking clenbuterol tablets. However, after taking clenbuterol tablets, some ratio points of the other six volunteers were between 0.9 and 1.0. A case of an abnormal cold and fever, which returned to normal after recovery, was also reported firstly. Conclusion: A change in R-(-)/S-(+)-clenbuterol was reported in the Chinese population initially. A ratio of 0.9 was recommended in doping related cases for the Chinese population.
基金：
Financial support was received from General Administration of Sport of China (funding number 2014B128) and relevant support
from the China Anti-Doping Agency
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区生化研究方法3 区分析化学
最新[2023]版：
大类|4 区医学
小类|4 区生化研究方法4 区分析化学
JCR分区：
出版当年[2018]版：
Q2CHEMISTRY, ANALYTICALQ3BIOCHEMICAL RESEARCH METHODS
最新[2023]版：
Q3BIOCHEMICAL RESEARCH METHODSQ3CHEMISTRY, ANALYTICAL
第一作者机构：[1]National Anti-Doping Laboratory, China Anti-Doping Agency, 1st Anding Road, Chaoyang District, Beijing 100029, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
He Genye,Sheng Linghui,Zhang Jianli,et al.Enantiomeric analysis of clenbuterol in Chinese people by LC-MS/MS to distinguish doping abuse from meat contamination.[J].BIOANALYSIS.2020,12(11):783-790.doi:10.4155/bio-2020-0003.
APA：
He Genye,Sheng Linghui,Zhang Jianli,Wu Yun,Zhao Xuxiao...&Lu Jianghai.(2020).Enantiomeric analysis of clenbuterol in Chinese people by LC-MS/MS to distinguish doping abuse from meat contamination..BIOANALYSIS,12,(11)
MLA：
He Genye,et al."Enantiomeric analysis of clenbuterol in Chinese people by LC-MS/MS to distinguish doping abuse from meat contamination.".BIOANALYSIS 12..11(2020):783-790
