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Analysis of MTR and MTRR Gene Polymorphisms in Chinese Patients With Ventricular Septal Defect

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收录情况： ◇ SCIE

作者：
Su, Jiang[1] * ; Li, Zhongzhi[1,*1] ;
机构： [1]Cardiac Centre, Beijing Children’s Hospital, Affiliated to Capital Medical University, Beijing, China.
出处：
DOI： 10.1097/PAI.0000000000000512
ISSN：

关键词： ventricular septal defects polymorphisms methionine synthase methionine synthase reductase folic acid

摘要：
Background:Congenital heart defects (CHDs) are the most common birth defects and ventricular septal defects (VSDs) are one of the most common types of CHDs. Genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase and methionine synthase reductase (MTRR) are key regulatory enzymes involved in the metabolic pathway of homocysteine.Methods:We investigated whether a polymorphism (A2756G) of the methionine synthase and 2 polymorphisms (A66G and C524T) of the MTRR gene are associated with VSDs. A total of 183 children with VSDs and 201 healthy children were studied.Results:The polymorphisms were detected by polymerase chain reaction amplification and sequencing of the amplified product. Significant differences in the distributions of the A66G and C524T alleles were observed between VSD cases and controls, and a slightly increased risk of VSDs was associated with either of the 66AG, 524CT, and 524TT genotypes [odds ratios (OR)=1.796, 1.909, and 2.088, respectively]. The genotype frequency of 66AG in VSDs patients was significantly different from those of controls (ORs=3.147). In addition, the combined 66AG/524CT and 66GG/524TT in VSDs had ORs 2.937 and 5.344, respectively.Conclusions:MTRR A66G and C524T polymorphisms are associated with increased risk of VSDs.

基金：
Received for publication August 12, 2016; accepted February 13, 2017. From the Cardiac Centre, Beijing Children’s Hospital, Affiliated to Capital Medical University, Beijing, China. Supported by a grant from the National Natural Science Foundation of China (No. 30672l 93). The authors declare no conflict of interest. Reprints: Zhongzhi Li, BM, Cardiac Centre, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing 100045, China (e-mail: [email protected]). Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 4 区 医学
小类 | 2 区 解剖学与形态学 4 区 医学实验技术 4 区 病理学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 解剖学与形态学 4 区 医学实验技术 4 区 病理学
JCR分区：
出版当年[2016]版：
Q2 ANATOMY & MORPHOLOGY Q3 PATHOLOGY Q3 MEDICAL LABORATORY TECHNOLOGY
最新[2023]版：
Q2 ANATOMY & MORPHOLOGY Q3 ANATOMY & MORPHOLOGY Q3 MEDICAL LABORATORY TECHNOLOGY Q3 PATHOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Cardiac Centre, Beijing Children’s Hospital, Affiliated to Capital Medical University, Beijing, China.
通讯作者：
通讯机构： [1]Cardiac Centre, Beijing Children’s Hospital, Affiliated to Capital Medical University, Beijing, China. [*1]Cardiac Centre, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing 100045, China
推荐引用方式(GB/T 7714)：
Su Jiang,Li Zhongzhi.Analysis of MTR and MTRR Gene Polymorphisms in Chinese Patients With Ventricular Septal Defect[J].APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY.2018,26(10):769-774.doi:10.1097/PAI.0000000000000512.
APA：
Su, Jiang&Li, Zhongzhi.(2018).Analysis of MTR and MTRR Gene Polymorphisms in Chinese Patients With Ventricular Septal Defect.APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,26,(10)
MLA：
Su, Jiang,et al."Analysis of MTR and MTRR Gene Polymorphisms in Chinese Patients With Ventricular Septal Defect".APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 26..10(2018):769-774

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